The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia

Kuei Y. Tseng, R. Chambers, Barbara K. Lipska

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Traditionally, animal models of schizophrenia were predominantly pharmacological constructs focused on phenomena linked to dopamine and glutamate neurotransmitter systems, and were created by direct perturbations of these systems. A number of developmental models were subsequently generated that allowed testing of hypotheses about the origin of the disease, mimicked a wider array of clinical and neurobiological features of schizophrenia, and opened new avenues for developing novel treatment strategies. The most thoroughly characterized (∼100 primary research articles) is the neonatal ventral hippocampal lesion (NVHL) model, which is the subject of this review. We highlight its advantages and limitations, and how it may offer clues about the extent to which positive, negative, cognitive, and other aspects of schizophrenia, including addiction vulnerability, represent inter-related pathophysiological mechanisms.

Original languageEnglish
Pages (from-to)295-305
Number of pages11
JournalBehavioural Brain Research
Volume204
Issue number2
DOIs
StatePublished - Dec 7 2009

Fingerprint

Schizophrenia
Neurotransmitter Agents
Glutamic Acid
Dopamine
Animal Models
Pharmacology
Research
Heuristics

Keywords

  • Dopamine
  • Interneurons
  • Neurodevelopment
  • Schizophrenia

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia. / Tseng, Kuei Y.; Chambers, R.; Lipska, Barbara K.

In: Behavioural Brain Research, Vol. 204, No. 2, 07.12.2009, p. 295-305.

Research output: Contribution to journalArticle

@article{92de0f993c694193a76610bd86b45822,
title = "The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia",
abstract = "Traditionally, animal models of schizophrenia were predominantly pharmacological constructs focused on phenomena linked to dopamine and glutamate neurotransmitter systems, and were created by direct perturbations of these systems. A number of developmental models were subsequently generated that allowed testing of hypotheses about the origin of the disease, mimicked a wider array of clinical and neurobiological features of schizophrenia, and opened new avenues for developing novel treatment strategies. The most thoroughly characterized (∼100 primary research articles) is the neonatal ventral hippocampal lesion (NVHL) model, which is the subject of this review. We highlight its advantages and limitations, and how it may offer clues about the extent to which positive, negative, cognitive, and other aspects of schizophrenia, including addiction vulnerability, represent inter-related pathophysiological mechanisms.",
keywords = "Dopamine, Interneurons, Neurodevelopment, Schizophrenia",
author = "Tseng, {Kuei Y.} and R. Chambers and Lipska, {Barbara K.}",
year = "2009",
month = "12",
day = "7",
doi = "10.1016/j.bbr.2008.11.039",
language = "English",
volume = "204",
pages = "295--305",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - The neonatal ventral hippocampal lesion as a heuristic neurodevelopmental model of schizophrenia

AU - Tseng, Kuei Y.

AU - Chambers, R.

AU - Lipska, Barbara K.

PY - 2009/12/7

Y1 - 2009/12/7

N2 - Traditionally, animal models of schizophrenia were predominantly pharmacological constructs focused on phenomena linked to dopamine and glutamate neurotransmitter systems, and were created by direct perturbations of these systems. A number of developmental models were subsequently generated that allowed testing of hypotheses about the origin of the disease, mimicked a wider array of clinical and neurobiological features of schizophrenia, and opened new avenues for developing novel treatment strategies. The most thoroughly characterized (∼100 primary research articles) is the neonatal ventral hippocampal lesion (NVHL) model, which is the subject of this review. We highlight its advantages and limitations, and how it may offer clues about the extent to which positive, negative, cognitive, and other aspects of schizophrenia, including addiction vulnerability, represent inter-related pathophysiological mechanisms.

AB - Traditionally, animal models of schizophrenia were predominantly pharmacological constructs focused on phenomena linked to dopamine and glutamate neurotransmitter systems, and were created by direct perturbations of these systems. A number of developmental models were subsequently generated that allowed testing of hypotheses about the origin of the disease, mimicked a wider array of clinical and neurobiological features of schizophrenia, and opened new avenues for developing novel treatment strategies. The most thoroughly characterized (∼100 primary research articles) is the neonatal ventral hippocampal lesion (NVHL) model, which is the subject of this review. We highlight its advantages and limitations, and how it may offer clues about the extent to which positive, negative, cognitive, and other aspects of schizophrenia, including addiction vulnerability, represent inter-related pathophysiological mechanisms.

KW - Dopamine

KW - Interneurons

KW - Neurodevelopment

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=69249237024&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69249237024&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2008.11.039

DO - 10.1016/j.bbr.2008.11.039

M3 - Article

VL - 204

SP - 295

EP - 305

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -