The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats

Improvement with l-arginine

Hamed Sadeghipour, Mehdi Dehghani, Mehdi Ghasemi, Kiarash Riazi, Shahrzad Asadi, Farzad Ebrahimi, Hooman Honar, Amir R. Hajrasouliha, Sina Tavakoli, Setareh Sianati, Ahmad Reza Dehpour

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (P < 0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME; 100 μM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor l-arginine, at per se noneffective concentration (0.1 mM), significantly (P < 0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by l-arginine.

Original languageEnglish (US)
Pages (from-to)300-305
Number of pages6
JournalEuropean Journal of Pharmacology
Volume586
Issue number1-3
DOIs
StatePublished - May 31 2008
Externally publishedYes

Fingerprint

Lithium
Electric Stimulation
Arginine
Nitric Oxide
Nitric Oxide Donors
Nitroprusside
Phenylephrine
Nitric Oxide Synthase
Therapeutics

Keywords

  • Corpus cavernosum
  • Erectile dysfunction
  • l-arginine
  • Lithium
  • Nitric oxide [NO]
  • Nonadrenergic noncholinergic [NANC] relaxation

ASJC Scopus subject areas

  • Pharmacology

Cite this

The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats : Improvement with l-arginine. / Sadeghipour, Hamed; Dehghani, Mehdi; Ghasemi, Mehdi; Riazi, Kiarash; Asadi, Shahrzad; Ebrahimi, Farzad; Honar, Hooman; Hajrasouliha, Amir R.; Tavakoli, Sina; Sianati, Setareh; Dehpour, Ahmad Reza.

In: European Journal of Pharmacology, Vol. 586, No. 1-3, 31.05.2008, p. 300-305.

Research output: Contribution to journalArticle

Sadeghipour, H, Dehghani, M, Ghasemi, M, Riazi, K, Asadi, S, Ebrahimi, F, Honar, H, Hajrasouliha, AR, Tavakoli, S, Sianati, S & Dehpour, AR 2008, 'The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine', European Journal of Pharmacology, vol. 586, no. 1-3, pp. 300-305. https://doi.org/10.1016/j.ejphar.2008.02.054
Sadeghipour, Hamed ; Dehghani, Mehdi ; Ghasemi, Mehdi ; Riazi, Kiarash ; Asadi, Shahrzad ; Ebrahimi, Farzad ; Honar, Hooman ; Hajrasouliha, Amir R. ; Tavakoli, Sina ; Sianati, Setareh ; Dehpour, Ahmad Reza. / The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats : Improvement with l-arginine. In: European Journal of Pharmacology. 2008 ; Vol. 586, No. 1-3. pp. 300-305.
@article{c4294443f7c64ed9b93637f9e853d6e5,
title = "The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine",
abstract = "One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (P < 0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME; 100 μM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor l-arginine, at per se noneffective concentration (0.1 mM), significantly (P < 0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by l-arginine.",
keywords = "Corpus cavernosum, Erectile dysfunction, l-arginine, Lithium, Nitric oxide [NO], Nonadrenergic noncholinergic [NANC] relaxation",
author = "Hamed Sadeghipour and Mehdi Dehghani and Mehdi Ghasemi and Kiarash Riazi and Shahrzad Asadi and Farzad Ebrahimi and Hooman Honar and Hajrasouliha, {Amir R.} and Sina Tavakoli and Setareh Sianati and Dehpour, {Ahmad Reza}",
year = "2008",
month = "5",
day = "31",
doi = "10.1016/j.ejphar.2008.02.054",
language = "English (US)",
volume = "586",
pages = "300--305",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats

T2 - Improvement with l-arginine

AU - Sadeghipour, Hamed

AU - Dehghani, Mehdi

AU - Ghasemi, Mehdi

AU - Riazi, Kiarash

AU - Asadi, Shahrzad

AU - Ebrahimi, Farzad

AU - Honar, Hooman

AU - Hajrasouliha, Amir R.

AU - Tavakoli, Sina

AU - Sianati, Setareh

AU - Dehpour, Ahmad Reza

PY - 2008/5/31

Y1 - 2008/5/31

N2 - One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (P < 0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME; 100 μM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor l-arginine, at per se noneffective concentration (0.1 mM), significantly (P < 0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by l-arginine.

AB - One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (P < 0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME; 100 μM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor l-arginine, at per se noneffective concentration (0.1 mM), significantly (P < 0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by l-arginine.

KW - Corpus cavernosum

KW - Erectile dysfunction

KW - l-arginine

KW - Lithium

KW - Nitric oxide [NO]

KW - Nonadrenergic noncholinergic [NANC] relaxation

UR - http://www.scopus.com/inward/record.url?scp=43549117467&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=43549117467&partnerID=8YFLogxK

U2 - 10.1016/j.ejphar.2008.02.054

DO - 10.1016/j.ejphar.2008.02.054

M3 - Article

VL - 586

SP - 300

EP - 305

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -