The nonadrenergic noncholinergic-mediated relaxation of corpus cavernosum was impaired in chronic lithium-treated rats: Improvement with l-arginine

Hamed Sadeghipour, Mehdi Dehghani, Mehdi Ghasemi, Kiarash Riazi, Shahrzad Asadi, Farzad Ebrahimi, Hooman Honar, Amir Reza Hajrasouliha, Sina Tavakoli, Setareh Sianati, Ahmad Reza Dehpour

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

One-third of lithium-treated men complain from sexual dysfunction, although the exact mechanisms of which are not yet known. In this study we investigated the effect of chronic lithium (LiCl, 600 mg/l for 30 days) administration on the neurogenic relaxation of isolated rat corpus cavernosum. The corporal strips were precontracted with phenylephrine and electrical field stimulation (EFS) was applied to obtain relaxation. Relaxation to EFS was significantly (P < 0.001) impaired in LiCl-treated rats. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME; 100 μM) inhibited the relaxation to EFS in both LiCl-treated and control rats. The NO precursor l-arginine, at per se noneffective concentration (0.1 mM), significantly (P < 0.001) enhanced the EFS-induced relaxation of LiCl-treated corporal strips. The relaxation responses to the NO donor sodium nitroprusside were similar between two groups. These data demonstrate that chronic lithium treatment could impair the NO-mediated neurogenic relaxation of rat corpus cavernosum which could be prevented by l-arginine.

Original languageEnglish (US)
Pages (from-to)300-305
Number of pages6
JournalEuropean Journal of Pharmacology
Volume586
Issue number1-3
DOIs
StatePublished - May 31 2008

Keywords

  • Corpus cavernosum
  • Erectile dysfunction
  • Lithium
  • Nitric oxide [NO]
  • Nonadrenergic noncholinergic [NANC] relaxation
  • l-arginine

ASJC Scopus subject areas

  • Pharmacology

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