The ontogeny of cardio-respiratory function under chronically altered gas compositions in Xenopus laevis

Paul R. Territo, Jordi Altimiras

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The importance of diffusion and perfusion in terms of oxygen transport was evaluated by chronically altering environmental O2 availability (hypoxia or hyperoxia) and blood O2 content (carbon monoxide) through development in Xenopus laevis. Oxygen consumption (M(O(2))), individual wet mass, heart rate (fh), and stroke volume (SV) were measured in animals raised from eggs to pre-metamorphic climax while maintained at 11, 21 and 35 kPa O2, combined with and without 2 kPa carbon monoxide. Additionally, cardiac output (Q), and a recently defined O2 consumption/transport quotient (M(O(2)).Q-1(O(2))) were calculated. Wet mass, M(O(2)), and fh, were not significantly different between controls and experimental treatments at any developmental stage. However, with hemoglobin oxygen transport blocked by carbon monoxide, the exposed larvae showed an increased SV, Q and M(O(2)).Q-1(O(2)). Combined, these data suggest that in spite of impaired blood O2 convection, normal aerobic metabolism was maintained, indicating that direct diffusion of O2 plays an important role in supplying oxygen during early development. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)311-323
Number of pages13
JournalRespiration Physiology
Volume111
Issue number3
DOIs
StatePublished - Mar 1 1998
Externally publishedYes

Keywords

  • African clawed frog (Xenopus laevis)
  • Amphibians
  • Development, egg
  • Egg, amphibian, O transport
  • Oxygen, transport

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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