The ontogeny of the gut-associated lymphoid tissue in short bowel syndrome

L. R. Scherer, W. E. Beschorner, P. M. Colombani

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Newborns suffering from short bowel syndrome (SBS) after massive intestinal resection have numerous infectious complications, which may be due to immunoincompetence from the loss of gut-associated lymphoid tissue (GALT). This study examines the ontogeny of GALT in the rat with SBS. A total of 36 3-week-old rats were divided into two groups: I, sham operated (C, n = 16); and II (SBS, n = 20), with a 50% resection of small intestine with jejunoileostomy. At 4, 5, 6, and 10 weeks of age the animals were sacrificed and the GALT was assessed by video analysis and immunoperoxidase monoclonal antibodies, OX8 (CD8), W-3/25 (CD4), and MARA-2 (IgA). The data were expressed as positive staining lymphocytes per 104 μm2 (mean ± SD). {A table is presented}.

Original languageEnglish (US)
Pages (from-to)358-362
Number of pages5
JournalJournal of Surgical Research
Volume48
Issue number4
DOIs
StatePublished - Apr 1990

ASJC Scopus subject areas

  • Surgery

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