The origin of prostate metastases

emerging insights

Matteo Santoni, Francesco Piva, Marina Scarpelli, Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Roberto Iacovelli, Rossana Berardi, Daniele Santini, Rodolfo Montironi

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The outcome of patients with prostate cancer (PCa) is mainly dependent on the presence or absence of distant metastases. Although several advances have been made in understanding the biological basis of this tumor, the mechanisms underlying PCa metastatic spread are not fully clear. The lack of a clear origin for PCa metastasis may be partially due to the evidence of PCa heterogeneity between primary tumor and metastases and among different metastatic sites. Cross-metastatic seeding and the de novo monoclonal seeding of daughter metastases have been proposed as crucial events during metastasis. This process requires the contribution of tumor environment, which modulates cancer cell homing and growth, and involves several components including cancer stem cells (CSCs), tumor secreted microvesicles, circulating tumor cells (CTCs), and immune cells. In this review, we have focused on the recent findings on the origin of prostate metastasis, showing the contribution of tumor microenvironment to this evolutionary process.

Original languageEnglish (US)
Pages (from-to)765-773
Number of pages9
JournalCancer and Metastasis Reviews
Volume34
Issue number4
DOIs
StatePublished - Dec 1 2015

Fingerprint

Prostate
Neoplasm Metastasis
Prostatic Neoplasms
Neoplasms
Circulating Neoplastic Cells
Tumor Microenvironment
Neoplastic Stem Cells
Growth

Keywords

  • Cancer stem cells
  • Circulating tumor cells
  • Exosomes
  • Inflammation
  • Metastasis
  • Prostate cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Santoni, M., Piva, F., Scarpelli, M., Cheng, L., Lopez-Beltran, A., Massari, F., ... Montironi, R. (2015). The origin of prostate metastases: emerging insights. Cancer and Metastasis Reviews, 34(4), 765-773. https://doi.org/10.1007/s10555-015-9597-6

The origin of prostate metastases : emerging insights. / Santoni, Matteo; Piva, Francesco; Scarpelli, Marina; Cheng, Liang; Lopez-Beltran, Antonio; Massari, Francesco; Iacovelli, Roberto; Berardi, Rossana; Santini, Daniele; Montironi, Rodolfo.

In: Cancer and Metastasis Reviews, Vol. 34, No. 4, 01.12.2015, p. 765-773.

Research output: Contribution to journalArticle

Santoni, M, Piva, F, Scarpelli, M, Cheng, L, Lopez-Beltran, A, Massari, F, Iacovelli, R, Berardi, R, Santini, D & Montironi, R 2015, 'The origin of prostate metastases: emerging insights', Cancer and Metastasis Reviews, vol. 34, no. 4, pp. 765-773. https://doi.org/10.1007/s10555-015-9597-6
Santoni M, Piva F, Scarpelli M, Cheng L, Lopez-Beltran A, Massari F et al. The origin of prostate metastases: emerging insights. Cancer and Metastasis Reviews. 2015 Dec 1;34(4):765-773. https://doi.org/10.1007/s10555-015-9597-6
Santoni, Matteo ; Piva, Francesco ; Scarpelli, Marina ; Cheng, Liang ; Lopez-Beltran, Antonio ; Massari, Francesco ; Iacovelli, Roberto ; Berardi, Rossana ; Santini, Daniele ; Montironi, Rodolfo. / The origin of prostate metastases : emerging insights. In: Cancer and Metastasis Reviews. 2015 ; Vol. 34, No. 4. pp. 765-773.
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