The P-value illusion: How to improve (psychiatric) genetic studies

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

There is an emerging appreciation that genome-wide association studies (GWAS) have failed to live up to expectations and deliver major advances to date. A "surge" strategy, of pooling resources and increasing number of subjects tested, is underway.Weargue that, while useful, itwill not be enough by itself. Complementary approaches are needed tomine these large datasets.Wedescribe a series of problems, opportunities, and offer a potential comprehensive solution.

Original languageEnglish (US)
Pages (from-to)847-849
Number of pages3
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume153
Issue number4
DOIs
StatePublished - Jun 1 2010

Keywords

  • Complexity
  • Convergent functional genomics (CFG)
  • Copy-number variants (CNV)
  • Genome-wide association studies (GWAS)
  • Psychiatric genetics

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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