The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord

Zhou Feng Chen, Sandra Rebelo, Fletcher White, Annika B. Malmberg, Hiroshi Baba, Deolinda Lima, Clifford J. Woolf, Allan I. Basbaum, David J. Anderson

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

Cutaneous sensory neurons that detect noxious stimuli project to the dorsal horn of the spinal cord, while those innervating muscle stretch receptors project to the ventral horn. DRG11, a paired homeodomain transcription factor, is expressed in both the developing dorsal horn and in sensory neurons, but not in the ventral spinal cord. Mouse embryos deficient in DRG11 display abnormalities in the spatio-temporal patterning of cutaneous sensory afferent fiber projections to the dorsal, but not the ventral spinal cord, as well as defects in dorsal horn morphogenesis. These early developmental abnormalities lead, in adults, to significantly attenuated sensitivity to noxious stimuli. In contrast, locomotion and sensori-motor functions appear normal. Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord.

Original languageEnglish (US)
Pages (from-to)59-73
Number of pages15
JournalNeuron
Volume31
Issue number1
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Homeodomain Proteins
Spinal Cord
Sensory Receptor Cells
Skin
Muscle Spindles
Nociceptors
Locomotion
Horns
Morphogenesis
Transcription Factors
Embryonic Structures
Spinal Cord Dorsal Horn

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. / Chen, Zhou Feng; Rebelo, Sandra; White, Fletcher; Malmberg, Annika B.; Baba, Hiroshi; Lima, Deolinda; Woolf, Clifford J.; Basbaum, Allan I.; Anderson, David J.

In: Neuron, Vol. 31, No. 1, 2001, p. 59-73.

Research output: Contribution to journalArticle

Chen, ZF, Rebelo, S, White, F, Malmberg, AB, Baba, H, Lima, D, Woolf, CJ, Basbaum, AI & Anderson, DJ 2001, 'The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord', Neuron, vol. 31, no. 1, pp. 59-73. https://doi.org/10.1016/S0896-6273(01)00341-5
Chen, Zhou Feng ; Rebelo, Sandra ; White, Fletcher ; Malmberg, Annika B. ; Baba, Hiroshi ; Lima, Deolinda ; Woolf, Clifford J. ; Basbaum, Allan I. ; Anderson, David J. / The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord. In: Neuron. 2001 ; Vol. 31, No. 1. pp. 59-73.
@article{2bec63ce1eff480598e3a1929b4d7f19,
title = "The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord",
abstract = "Cutaneous sensory neurons that detect noxious stimuli project to the dorsal horn of the spinal cord, while those innervating muscle stretch receptors project to the ventral horn. DRG11, a paired homeodomain transcription factor, is expressed in both the developing dorsal horn and in sensory neurons, but not in the ventral spinal cord. Mouse embryos deficient in DRG11 display abnormalities in the spatio-temporal patterning of cutaneous sensory afferent fiber projections to the dorsal, but not the ventral spinal cord, as well as defects in dorsal horn morphogenesis. These early developmental abnormalities lead, in adults, to significantly attenuated sensitivity to noxious stimuli. In contrast, locomotion and sensori-motor functions appear normal. Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord.",
author = "Chen, {Zhou Feng} and Sandra Rebelo and Fletcher White and Malmberg, {Annika B.} and Hiroshi Baba and Deolinda Lima and Woolf, {Clifford J.} and Basbaum, {Allan I.} and Anderson, {David J.}",
year = "2001",
doi = "10.1016/S0896-6273(01)00341-5",
language = "English (US)",
volume = "31",
pages = "59--73",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - The paired homeodomain protein DRG11 is required for the projection of cutaneous sensory afferent fibers to the dorsal spinal cord

AU - Chen, Zhou Feng

AU - Rebelo, Sandra

AU - White, Fletcher

AU - Malmberg, Annika B.

AU - Baba, Hiroshi

AU - Lima, Deolinda

AU - Woolf, Clifford J.

AU - Basbaum, Allan I.

AU - Anderson, David J.

PY - 2001

Y1 - 2001

N2 - Cutaneous sensory neurons that detect noxious stimuli project to the dorsal horn of the spinal cord, while those innervating muscle stretch receptors project to the ventral horn. DRG11, a paired homeodomain transcription factor, is expressed in both the developing dorsal horn and in sensory neurons, but not in the ventral spinal cord. Mouse embryos deficient in DRG11 display abnormalities in the spatio-temporal patterning of cutaneous sensory afferent fiber projections to the dorsal, but not the ventral spinal cord, as well as defects in dorsal horn morphogenesis. These early developmental abnormalities lead, in adults, to significantly attenuated sensitivity to noxious stimuli. In contrast, locomotion and sensori-motor functions appear normal. Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord.

AB - Cutaneous sensory neurons that detect noxious stimuli project to the dorsal horn of the spinal cord, while those innervating muscle stretch receptors project to the ventral horn. DRG11, a paired homeodomain transcription factor, is expressed in both the developing dorsal horn and in sensory neurons, but not in the ventral spinal cord. Mouse embryos deficient in DRG11 display abnormalities in the spatio-temporal patterning of cutaneous sensory afferent fiber projections to the dorsal, but not the ventral spinal cord, as well as defects in dorsal horn morphogenesis. These early developmental abnormalities lead, in adults, to significantly attenuated sensitivity to noxious stimuli. In contrast, locomotion and sensori-motor functions appear normal. Drg11 is thus required for the formation of spatio-temporally appropriate projections from nociceptive sensory neurons to their central targets in the dorsal horn of the spinal cord.

UR - http://www.scopus.com/inward/record.url?scp=0034889110&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034889110&partnerID=8YFLogxK

U2 - 10.1016/S0896-6273(01)00341-5

DO - 10.1016/S0896-6273(01)00341-5

M3 - Article

C2 - 11498051

AN - SCOPUS:0034889110

VL - 31

SP - 59

EP - 73

JO - Neuron

JF - Neuron

SN - 0896-6273

IS - 1

ER -