The pathogenesis of diabetic retinopathy

Old concepts and new questions

J. Cai, M. Boulton

Research output: Contribution to journalArticle

207 Citations (Scopus)

Abstract

Hyperglycaemia appears to be a critical factor in the aetiology of diabetic retinopathy and initiates downstream events including: basement membrane thickening, pericyte drop out and retinal capillary non-perfusion. More recently, focus has been directed to the molecular basis of the disease process in diabetic retinopathy. Of particular importance in the development and progression of diabetic retinopathy is the role of growth factors (eg vascular endothelial growth factor, placenta growth factor and pigment epithelium-derived factor) together with specific receptors and obligate components of the signal transduction pathway needed to support them. Despite these advances there are still a number of important questions that remain to be answered before we can confidently target pathological signals. How does hyperglycaemia regulate retinal vessels? Which growth factors are most important and at what stage of retinopathy do they operate? What is the preferred point in the growth factor signalling cascade for therapeutic intervention? Answers to these questions will provide the basis for new therapeutic interventions in a debilitating ocular condition.

Original languageEnglish (US)
Pages (from-to)242-260
Number of pages19
JournalEye (Basingstoke)
Volume16
Issue number3
DOIs
StatePublished - 2002
Externally publishedYes

Fingerprint

Diabetic Retinopathy
Intercellular Signaling Peptides and Proteins
Hyperglycemia
Retinal Vessels
Pericytes
Basement Membrane
Vascular Endothelial Growth Factor A
Signal Transduction
Therapeutics

Keywords

  • Diabetic retinopathy
  • Growth factor
  • Hyperglycaemia
  • Hypoxia
  • Neovascularization
  • Pericytes
  • Retina endothelial cells

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

Cite this

The pathogenesis of diabetic retinopathy : Old concepts and new questions. / Cai, J.; Boulton, M.

In: Eye (Basingstoke), Vol. 16, No. 3, 2002, p. 242-260.

Research output: Contribution to journalArticle

Cai, J. ; Boulton, M. / The pathogenesis of diabetic retinopathy : Old concepts and new questions. In: Eye (Basingstoke). 2002 ; Vol. 16, No. 3. pp. 242-260.
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