The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales: A systematic review

Kurt Kroenke, Robert L. Spitzer, Janet B W Williams, Bernd Löwe

Research output: Contribution to journalArticle

1053 Citations (Scopus)

Abstract

Background: Depression, anxiety and somatization are the most common mental disorders in primary care as well as medical specialty populations; each is present in at least 5-10% of patients and frequently comorbid with one another. An efficient means for measuring and monitoring all three conditions would be desirable. Methods: Evidence regarding the psychometric and pragmatic characteristics of the Patient Health Questionnaire (PHQ)-9 depression, generalized anxiety disorder (GAD)-7 anxiety and PHQ-15 somatic symptom scales are synthesized from two sources: (1) four multisite cross-sectional studies (three conducted in primary care and one in obstetric-gynecology practices) comprising 9740 patients, and (2) key studies from the literature that have studied these scales. Results: The PHQ-9 and its abbreviated eight-item (PHQ-8) and two-item (PHQ-2) versions have good sensitivity and specificity for detecting depressive disorders. Likewise, the GAD-7 and its abbreviated two-item (GAD-2) version have good operating characteristics for detecting generalized anxiety, panic, social anxiety and post-traumatic stress disorder. The optimal cutpoint is ≥10 on the parent scales (PHQ-9 and GAD-7) and ≥3 on the ultra-brief versions (PHQ-2 and GAD-2). The PHQ-15 is equal or superior to other brief measures for assessing somatic symptoms and screening for somatoform disorders. Cutpoints of 5, 10 and 15 represent mild, moderate and severe symptom levels on all three scales. Sensitivity to change is well-established for the PHQ-9 and emerging albeit not yet definitive for the GAD-7 and PHQ-15. Conclusions: The PHQ-9, GAD-7 and PHQ-15 are brief well-validated measures for detecting and monitoring depression, anxiety and somatization.

Original languageEnglish
Pages (from-to)345-359
Number of pages15
JournalGeneral Hospital Psychiatry
Volume32
Issue number4
DOIs
StatePublished - Jul 2010

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Anxiety
Depression
Health
Anxiety Disorders
Surveys and Questionnaires
Medically Unexplained Symptoms
Primary Health Care
Somatoform Disorders
Panic
Depressive Disorder
Post-Traumatic Stress Disorders
Gynecology
Psychometrics
Mental Disorders
Obstetrics
Cross-Sectional Studies
Medicine
Sensitivity and Specificity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Medicine(all)

Cite this

The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales : A systematic review. / Kroenke, Kurt; Spitzer, Robert L.; Williams, Janet B W; Löwe, Bernd.

In: General Hospital Psychiatry, Vol. 32, No. 4, 07.2010, p. 345-359.

Research output: Contribution to journalArticle

Kroenke, Kurt ; Spitzer, Robert L. ; Williams, Janet B W ; Löwe, Bernd. / The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales : A systematic review. In: General Hospital Psychiatry. 2010 ; Vol. 32, No. 4. pp. 345-359.
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