The Pharmacogenetics Research Network: From SNP discovery to clinical drug response

K. M. Giacomini, C. M. Brett, R. B. Altman, N. L. Benowitz, M. E. Dolan, D. A. Flockhart, J. A. Johnson, D. F. Hayes, T. Klein, R. M. Krauss, D. L. Kroetz, H. L. McLeod, A. T. Nguyen, M. J. Ratain, M. V. Relling, V. Reus, D. M. Roden, C. A. Schaefer, A. R. Shuldiner, Todd SkaarK. Tantisira, R. F. Tyndale, L. Wang, R. M. Weinshilboum, S. T. Weiss, I. Zineh

Research output: Contribution to journalArticle

178 Citations (Scopus)

Abstract

The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators with a wide range of research interests, but all attempting to correlate drug response with genetic variation. Several research groups concentrate on drugs used to treat specific medical disorders (asthma, depression, cardiovascular disease, addiction of nicotine, and cancer), whereas others are focused on specific groups of proteins that interact with drugs (membrane transporters and phase II drug-metabolizing enzymes). The diverse scientific information is stored and annotated in a publicly accessible knowledge base, the Pharmacogenetics and Pharmacogenomics Knowledge base (PharmGKB). This report highlights selected achievements and scientific approaches as well as hypotheses about future directions of each of the groups within the PGRN. Seven major topics are included: informatics (PharmGKB), cardiovascular, pulmonary, addiction, cancer, transport, and metabolism.

Original languageEnglish
Pages (from-to)328-345
Number of pages18
JournalClinical Pharmacology and Therapeutics
Volume81
Issue number3
DOIs
StatePublished - Mar 2007

Fingerprint

Pharmacogenetics
Single Nucleotide Polymorphism
Knowledge Bases
Research
Pharmaceutical Preparations
Informatics
Membrane Transport Proteins
Nicotine
Lung Neoplasms
Cardiovascular Diseases
Asthma
Research Personnel
Depression
Enzymes
Neoplasms
Proteins

ASJC Scopus subject areas

  • Pharmacology

Cite this

Giacomini, K. M., Brett, C. M., Altman, R. B., Benowitz, N. L., Dolan, M. E., Flockhart, D. A., ... Zineh, I. (2007). The Pharmacogenetics Research Network: From SNP discovery to clinical drug response. Clinical Pharmacology and Therapeutics, 81(3), 328-345. https://doi.org/10.1038/sj.clpt.6100087

The Pharmacogenetics Research Network : From SNP discovery to clinical drug response. / Giacomini, K. M.; Brett, C. M.; Altman, R. B.; Benowitz, N. L.; Dolan, M. E.; Flockhart, D. A.; Johnson, J. A.; Hayes, D. F.; Klein, T.; Krauss, R. M.; Kroetz, D. L.; McLeod, H. L.; Nguyen, A. T.; Ratain, M. J.; Relling, M. V.; Reus, V.; Roden, D. M.; Schaefer, C. A.; Shuldiner, A. R.; Skaar, Todd; Tantisira, K.; Tyndale, R. F.; Wang, L.; Weinshilboum, R. M.; Weiss, S. T.; Zineh, I.

In: Clinical Pharmacology and Therapeutics, Vol. 81, No. 3, 03.2007, p. 328-345.

Research output: Contribution to journalArticle

Giacomini, KM, Brett, CM, Altman, RB, Benowitz, NL, Dolan, ME, Flockhart, DA, Johnson, JA, Hayes, DF, Klein, T, Krauss, RM, Kroetz, DL, McLeod, HL, Nguyen, AT, Ratain, MJ, Relling, MV, Reus, V, Roden, DM, Schaefer, CA, Shuldiner, AR, Skaar, T, Tantisira, K, Tyndale, RF, Wang, L, Weinshilboum, RM, Weiss, ST & Zineh, I 2007, 'The Pharmacogenetics Research Network: From SNP discovery to clinical drug response', Clinical Pharmacology and Therapeutics, vol. 81, no. 3, pp. 328-345. https://doi.org/10.1038/sj.clpt.6100087
Giacomini, K. M. ; Brett, C. M. ; Altman, R. B. ; Benowitz, N. L. ; Dolan, M. E. ; Flockhart, D. A. ; Johnson, J. A. ; Hayes, D. F. ; Klein, T. ; Krauss, R. M. ; Kroetz, D. L. ; McLeod, H. L. ; Nguyen, A. T. ; Ratain, M. J. ; Relling, M. V. ; Reus, V. ; Roden, D. M. ; Schaefer, C. A. ; Shuldiner, A. R. ; Skaar, Todd ; Tantisira, K. ; Tyndale, R. F. ; Wang, L. ; Weinshilboum, R. M. ; Weiss, S. T. ; Zineh, I. / The Pharmacogenetics Research Network : From SNP discovery to clinical drug response. In: Clinical Pharmacology and Therapeutics. 2007 ; Vol. 81, No. 3. pp. 328-345.
@article{3e30595d0cd5419595e451b8616a6765,
title = "The Pharmacogenetics Research Network: From SNP discovery to clinical drug response",
abstract = "The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators with a wide range of research interests, but all attempting to correlate drug response with genetic variation. Several research groups concentrate on drugs used to treat specific medical disorders (asthma, depression, cardiovascular disease, addiction of nicotine, and cancer), whereas others are focused on specific groups of proteins that interact with drugs (membrane transporters and phase II drug-metabolizing enzymes). The diverse scientific information is stored and annotated in a publicly accessible knowledge base, the Pharmacogenetics and Pharmacogenomics Knowledge base (PharmGKB). This report highlights selected achievements and scientific approaches as well as hypotheses about future directions of each of the groups within the PGRN. Seven major topics are included: informatics (PharmGKB), cardiovascular, pulmonary, addiction, cancer, transport, and metabolism.",
author = "Giacomini, {K. M.} and Brett, {C. M.} and Altman, {R. B.} and Benowitz, {N. L.} and Dolan, {M. E.} and Flockhart, {D. A.} and Johnson, {J. A.} and Hayes, {D. F.} and T. Klein and Krauss, {R. M.} and Kroetz, {D. L.} and McLeod, {H. L.} and Nguyen, {A. T.} and Ratain, {M. J.} and Relling, {M. V.} and V. Reus and Roden, {D. M.} and Schaefer, {C. A.} and Shuldiner, {A. R.} and Todd Skaar and K. Tantisira and Tyndale, {R. F.} and L. Wang and Weinshilboum, {R. M.} and Weiss, {S. T.} and I. Zineh",
year = "2007",
month = "3",
doi = "10.1038/sj.clpt.6100087",
language = "English",
volume = "81",
pages = "328--345",
journal = "Clinical Pharmacology and Therapeutics",
issn = "0009-9236",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - The Pharmacogenetics Research Network

T2 - From SNP discovery to clinical drug response

AU - Giacomini, K. M.

AU - Brett, C. M.

AU - Altman, R. B.

AU - Benowitz, N. L.

AU - Dolan, M. E.

AU - Flockhart, D. A.

AU - Johnson, J. A.

AU - Hayes, D. F.

AU - Klein, T.

AU - Krauss, R. M.

AU - Kroetz, D. L.

AU - McLeod, H. L.

AU - Nguyen, A. T.

AU - Ratain, M. J.

AU - Relling, M. V.

AU - Reus, V.

AU - Roden, D. M.

AU - Schaefer, C. A.

AU - Shuldiner, A. R.

AU - Skaar, Todd

AU - Tantisira, K.

AU - Tyndale, R. F.

AU - Wang, L.

AU - Weinshilboum, R. M.

AU - Weiss, S. T.

AU - Zineh, I.

PY - 2007/3

Y1 - 2007/3

N2 - The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators with a wide range of research interests, but all attempting to correlate drug response with genetic variation. Several research groups concentrate on drugs used to treat specific medical disorders (asthma, depression, cardiovascular disease, addiction of nicotine, and cancer), whereas others are focused on specific groups of proteins that interact with drugs (membrane transporters and phase II drug-metabolizing enzymes). The diverse scientific information is stored and annotated in a publicly accessible knowledge base, the Pharmacogenetics and Pharmacogenomics Knowledge base (PharmGKB). This report highlights selected achievements and scientific approaches as well as hypotheses about future directions of each of the groups within the PGRN. Seven major topics are included: informatics (PharmGKB), cardiovascular, pulmonary, addiction, cancer, transport, and metabolism.

AB - The NIH Pharmacogenetics Research Network (PGRN) is a collaborative group of investigators with a wide range of research interests, but all attempting to correlate drug response with genetic variation. Several research groups concentrate on drugs used to treat specific medical disorders (asthma, depression, cardiovascular disease, addiction of nicotine, and cancer), whereas others are focused on specific groups of proteins that interact with drugs (membrane transporters and phase II drug-metabolizing enzymes). The diverse scientific information is stored and annotated in a publicly accessible knowledge base, the Pharmacogenetics and Pharmacogenomics Knowledge base (PharmGKB). This report highlights selected achievements and scientific approaches as well as hypotheses about future directions of each of the groups within the PGRN. Seven major topics are included: informatics (PharmGKB), cardiovascular, pulmonary, addiction, cancer, transport, and metabolism.

UR - http://www.scopus.com/inward/record.url?scp=33847641458&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847641458&partnerID=8YFLogxK

U2 - 10.1038/sj.clpt.6100087

DO - 10.1038/sj.clpt.6100087

M3 - Article

C2 - 17339863

AN - SCOPUS:33847641458

VL - 81

SP - 328

EP - 345

JO - Clinical Pharmacology and Therapeutics

JF - Clinical Pharmacology and Therapeutics

SN - 0009-9236

IS - 3

ER -