The Phosphoinositide-3 kinase survival signaling mechanism in sepsis

Mariuxi C. Manukyan, Brent R. Weil, Yue Wang, Aaron M. Abarbanell, Jeremy L. Herrmann, Jeffrey A. Poynter, Daniel R. Meldrum

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)442-449
Number of pages8
JournalShock
Volume34
Issue number5
DOIs
StatePublished - Nov 2010
Externally publishedYes

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1-Phosphatidylinositol 4-Kinase
Sepsis
Adaptive Immunity
Innate Immunity
Cellular Immunity
Inflammation
Proteins
Therapeutics

Keywords

  • host defense
  • immune response
  • inflammation
  • PI3K
  • septic shock

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Emergency Medicine

Cite this

Manukyan, M. C., Weil, B. R., Wang, Y., Abarbanell, A. M., Herrmann, J. L., Poynter, J. A., & Meldrum, D. R. (2010). The Phosphoinositide-3 kinase survival signaling mechanism in sepsis. Shock, 34(5), 442-449. https://doi.org/10.1097/SHK.0b013e3181e14ea9

The Phosphoinositide-3 kinase survival signaling mechanism in sepsis. / Manukyan, Mariuxi C.; Weil, Brent R.; Wang, Yue; Abarbanell, Aaron M.; Herrmann, Jeremy L.; Poynter, Jeffrey A.; Meldrum, Daniel R.

In: Shock, Vol. 34, No. 5, 11.2010, p. 442-449.

Research output: Contribution to journalArticle

Manukyan, MC, Weil, BR, Wang, Y, Abarbanell, AM, Herrmann, JL, Poynter, JA & Meldrum, DR 2010, 'The Phosphoinositide-3 kinase survival signaling mechanism in sepsis', Shock, vol. 34, no. 5, pp. 442-449. https://doi.org/10.1097/SHK.0b013e3181e14ea9
Manukyan MC, Weil BR, Wang Y, Abarbanell AM, Herrmann JL, Poynter JA et al. The Phosphoinositide-3 kinase survival signaling mechanism in sepsis. Shock. 2010 Nov;34(5):442-449. https://doi.org/10.1097/SHK.0b013e3181e14ea9
Manukyan, Mariuxi C. ; Weil, Brent R. ; Wang, Yue ; Abarbanell, Aaron M. ; Herrmann, Jeremy L. ; Poynter, Jeffrey A. ; Meldrum, Daniel R. / The Phosphoinositide-3 kinase survival signaling mechanism in sepsis. In: Shock. 2010 ; Vol. 34, No. 5. pp. 442-449.
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