The photoreactivity of ocular lipofuscin

Mike Boulton, Malgorzata Rózanowska, Bartosz Rözanowski, Tim Wess

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Lipofuscin or "age pigment" is a lipid-protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity. This is particularly so in the retina in which the lipofuscin not only contains retinoid metabolites but is also exposed to high oxygen and fluxes of visible light all of which provide an ideal environment for the generation of reactive oxygen species (ROS). Lipofuscin is a potent photoinducible generator of ROS with the potential to damage proteins, lipids and DNA. Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss.

Original languageEnglish (US)
Pages (from-to)759-764
Number of pages6
JournalPhotochemical and Photobiological Sciences
Volume3
Issue number8
DOIs
StatePublished - Aug 2004
Externally publishedYes

Fingerprint

Photoreactivity
Lipofuscin
lipids
oxygen
proteins
Reactive Oxygen Species
retina
metabolites
pigments
Lipids
Retinoids
generators
deoxyribonucleic acid
Metabolites
Pigments
degradation
damage
Retina
Proteins
Cells

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics

Cite this

Boulton, M., Rózanowska, M., Rözanowski, B., & Wess, T. (2004). The photoreactivity of ocular lipofuscin. Photochemical and Photobiological Sciences, 3(8), 759-764. https://doi.org/10.1039/b400108g

The photoreactivity of ocular lipofuscin. / Boulton, Mike; Rózanowska, Malgorzata; Rözanowski, Bartosz; Wess, Tim.

In: Photochemical and Photobiological Sciences, Vol. 3, No. 8, 08.2004, p. 759-764.

Research output: Contribution to journalArticle

Boulton, M, Rózanowska, M, Rözanowski, B & Wess, T 2004, 'The photoreactivity of ocular lipofuscin', Photochemical and Photobiological Sciences, vol. 3, no. 8, pp. 759-764. https://doi.org/10.1039/b400108g
Boulton M, Rózanowska M, Rözanowski B, Wess T. The photoreactivity of ocular lipofuscin. Photochemical and Photobiological Sciences. 2004 Aug;3(8):759-764. https://doi.org/10.1039/b400108g
Boulton, Mike ; Rózanowska, Malgorzata ; Rözanowski, Bartosz ; Wess, Tim. / The photoreactivity of ocular lipofuscin. In: Photochemical and Photobiological Sciences. 2004 ; Vol. 3, No. 8. pp. 759-764.
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