The photoreactivity of ocular lipofuscin

Mike Boulton, Malgorzata Rózanowska, Bartosz Rózanowski, Tim Wess

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47 Scopus citations

Abstract

Lipofuscin or “age pigment” is a lipid–protein complex which accumulates in a variety of postmitotic, metabolically active cells throughout the body. These complexes, which are thought to result from the incomplete degradation of oxidised substrate, have the potential for photoreactivity. This is particularly so in the retina in which the lipofuscin not only contains retinoid metabolites but is also exposed to high oxygen and fluxes of visible light all of which provide an ideal environment for the generation of reactive oxygen species (ROS). Lipofuscin is a potent photoinducible generator of ROS with the potential to damage proteins, lipids and DNA. Retinal cell dysfunction may be strongly associated with photoreactivity of lipofuscin and may contribute to age-related disease and vision loss.

Original languageEnglish (US)
Pages (from-to)759-764
Number of pages6
JournalPhotochemical and Photobiological Sciences
Volume3
Issue number8
DOIs
StatePublished - Aug 4 2004

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Boulton, M., Rózanowska, M., Rózanowski, B., & Wess, T. (2004). The photoreactivity of ocular lipofuscin. Photochemical and Photobiological Sciences, 3(8), 759-764. https://doi.org/10.1039/b400108g