The post-transurethral resection of prostate syndrome

Therapeutic proposals

Rajiv Agarwal, M. Emmett

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Absorption of large volumes of irrigation fluid during transurethral resection of the prostate (TURP) can produce hyponatremia, coma, blindness, and cardiorespiratory depression. This has been termed the 'post-TURP syndrome.' The pathophysiology and management of this syndrome are controversial. A case of severe post-TURP syndrome due to the absorption of hypotonic glycine irrigant is reported. This patient developed severe hyponatremia, slight hypo-osmolality, hyperglycinemia, hyperserinemia, hyperammonemia, and hypocalcemia. He became comatose, profoundly hypotensive, bradycardic, and transiently blind. Because of this combination of severe biochemical, neurologic, and hemodynamic abnormalities, we elected to treat this patient with hemodialysis. The biochemical and clinical manifestations resolved completely. The pathophysiology and treatment of this disorder are discussed and a role for hemodialysis is suggested.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalAmerican Journal of Kidney Diseases
Volume24
Issue number1
StatePublished - 1994
Externally publishedYes

Fingerprint

Transurethral Resection of Prostate
Hyponatremia
Coma
Renal Dialysis
Nervous System Malformations
Hyperammonemia
Hypocalcemia
Blindness
Osmolar Concentration
Glycine
Therapeutics
Hemodynamics

ASJC Scopus subject areas

  • Nephrology

Cite this

The post-transurethral resection of prostate syndrome : Therapeutic proposals. / Agarwal, Rajiv; Emmett, M.

In: American Journal of Kidney Diseases, Vol. 24, No. 1, 1994, p. 108-111.

Research output: Contribution to journalArticle

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