The Post-Transurethral Resection of Prostate Syndrome: Therapeutic Proposals

Rajiv Agarwal, Michael Emmett

Research output: Contribution to journalArticle

41 Scopus citations


Absorption of large volumes of irrigation fluid during transurethral resection of the prostate (TURP) can produce hyponatremia, coma, blindness, and cardiorespiratory depression. This has been termed the “post-TURP syndrome”. The pathophysiology and management of this syndrome are controversial. A case of severe post-TURP syndrome due to the absorption of hypotonic glycine irrigant is reported. This patient developed severe hyponatremia, slight hypo-osmolality, hyperglycinemia, hyperserinemia, hyperammonemia, and hypocalcemia. He became comatose, profoundly hypotensive, bradycardic, and transiently blind. Because of this combination of severe biochemical, neurologic, and hemodynamic abnormalities, we elected to treat this patient with hemodialysis. The biochemical and clinical manifestations resolved completely. The pathophysiology and treatment of this disorder are discussed and a role for hemodialysis is suggested.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalAmerican Journal of Kidney Diseases
Issue number1
StatePublished - Jan 1 1994
Externally publishedYes


  • Glycine
  • coma
  • hemodialysis
  • hyponatremia
  • transurethral resection of prostate

ASJC Scopus subject areas

  • Nephrology

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