The potential of sestrins as therapeutic targets for diabetes

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Sestrins (Sesn1/2/3) belong to a small protein family that has versatile biological functions. In addition to initially characterized oxidoreductase activity, sestrins also have oxidoreductase-independent functions, including activation of AMP-activated protein kinase, inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) and activation of mTORC2. As these kinases are important for metabolic regulation, sestrins have a favorable profile as potential therapeutic targets for metabolic diseases such as diabetes. Recent data are in line with such a notion. In this editorial, I have attempted to provide a brief update on the major findings in regard to sestrins in metabolism.

Original languageEnglish (US)
Pages (from-to)1011-1015
Number of pages5
JournalExpert Opinion on Therapeutic Targets
Volume19
Issue number8
DOIs
StatePublished - Aug 1 2015

Keywords

  • Mechanistic target of rapamycin complex 1
  • mechanistic target of rapamycin complex 2
  • sestrin
  • v-akt murine thymoma viral oncogene homolog

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

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