The predominance of binucleation in isolated rat heart myocytes

A. A. Katzberg, B. B. Farmer, Robert Harris

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Myocytes of the heart of the newborn rat are mononucleated, whereas myocytes of the heart of growing, maturing rats become predominantly binucleated. This appears to be explained by mitotic division shortly after birth without cell division, i.e., karyokinesis without cytokinesis. Myocytes isolated from hearts of adult guinea pig and pigeon are also predominantly binucleated. Although only about an eighth of the cells of adult rat hearts are myocytes, most of the increase in size of the heart from birth to 6 mth can be accounted for by change in size of these cells.

Original languageEnglish
Pages (from-to)489-499
Number of pages11
JournalAmerican Journal of Anatomy
Volume149
Issue number4
StatePublished - 1977

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Muscle Cells
Parturition
Cell Nucleus Division
Cytokinesis
Columbidae
Cell Size
Cell Division
Guinea Pigs

ASJC Scopus subject areas

  • Anatomy

Cite this

The predominance of binucleation in isolated rat heart myocytes. / Katzberg, A. A.; Farmer, B. B.; Harris, Robert.

In: American Journal of Anatomy, Vol. 149, No. 4, 1977, p. 489-499.

Research output: Contribution to journalArticle

Katzberg, A. A. ; Farmer, B. B. ; Harris, Robert. / The predominance of binucleation in isolated rat heart myocytes. In: American Journal of Anatomy. 1977 ; Vol. 149, No. 4. pp. 489-499.
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