The prevention of extra cardiac conduit obstruction: An experimental study

Andrew C. Fiore, Pamela S. Peigh, Nicholas J. Sears, William P. Deschner, John Brown

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acquired right ventricular (RV) extracardiac conduit (ECC) obstruction was studied in an animal model. A 16 mm woven Dacron tube graft was inserted between the right ventricle (RV) and main pulmonary artery (PA) in 18 adult mongrel dogs followed by pulmonary artery occlusion with a Dacron tape. In 9 dogs, the RV anastomosis was maintained with a 16 mm Dacron covered polypropylene stent. The remaining 9 animals with direct suture attachment of the graft to the myocardium served as controls. Cardiac output and transconduit resistance were measured at operation, 6 months, and 1 year. The cardiac output remained the same in both groups. Animals with stented ECC showed little change in transconduit resistance and had a widely patent RV anastomosis at 1 year. Unstented conduits had increased transconduit resistance at 6 months and 1 year (P < 0.002). Postmortem examination showed fibromuscular ingrowth of the ventricular anastomosis to be the site of the acquired obstruction in unstented extracardiac conduits. The inclusion of a rigid stent in RV-ECC may warrant clinical application to prevent fibromuscular ingrowth and late RV anastomotic obstruction.

Original languageEnglish
Pages (from-to)463-472
Number of pages10
JournalJournal of Surgical Research
Volume34
Issue number5
DOIs
StatePublished - 1983

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Polyethylene Terephthalates
Cardiac Output
Pulmonary Artery
Stents
Dogs
Transplants
Polypropylenes
Sutures
Heart Ventricles
Autopsy
Myocardium
Animal Models

ASJC Scopus subject areas

  • Surgery

Cite this

The prevention of extra cardiac conduit obstruction : An experimental study. / Fiore, Andrew C.; Peigh, Pamela S.; Sears, Nicholas J.; Deschner, William P.; Brown, John.

In: Journal of Surgical Research, Vol. 34, No. 5, 1983, p. 463-472.

Research output: Contribution to journalArticle

Fiore, Andrew C. ; Peigh, Pamela S. ; Sears, Nicholas J. ; Deschner, William P. ; Brown, John. / The prevention of extra cardiac conduit obstruction : An experimental study. In: Journal of Surgical Research. 1983 ; Vol. 34, No. 5. pp. 463-472.
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