The prognosis of hyponatremia at hospital admission

William M. Tierney, Douglas K. Martin, M. Carol Greenlee, Robert L. Zerbe, Clement J. McDonald

Research output: Contribution to journalArticle

95 Scopus citations


To assess the risk of mortality in patients with hyponatremia at the time of hospital admission, the authors studied data for 13,979 patients admitted over a 46-month period. Of the 763 (4%) admitted with hyponatremia, 757 (99%) were matched by age, gender, and admitting date with normonatremic control patients. Hyponatremic patients were more than seven times as likely to die in the hospital than the control patients, and they were more than twice as likely to die after discharge (p<0.0001 for both). This relationship with in- and outpatient mortality held when controlling for the diagnoses found more often in the hyponatremic patients. Hyponatremia appears to be an indicator of increased risk of death regardless of the disease with which it is associated.

Original languageEnglish (US)
Pages (from-to)380-385
Number of pages6
JournalJournal of general internal medicine
Issue number6
StatePublished - Nov 1 1986
Externally publishedYes


  • clinical epidemiology
  • hyponatremia
  • mortality

ASJC Scopus subject areas

  • Internal Medicine

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    Tierney, W. M., Martin, D. K., Greenlee, M. C., Zerbe, R. L., & McDonald, C. J. (1986). The prognosis of hyponatremia at hospital admission. Journal of general internal medicine, 1(6), 380-385.