The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction

Xin Yuan Fu, Chris Schindler, Teresa Improta, Ruedi Aebersold, James E. Darnell

Research output: Contribution to journalArticle

412 Citations (Scopus)

Abstract

ISGF-3 is a multiprotein transcription factor that is very quickly activated in the cell cytoplasm only after attachment of interferon α to the cell surface. To understand the specific cytoplasmic activation of proteins that move to the nucleus and direct increased transcription of specific genes, we have purified and now report completion of the cloning of cDNA encoding the four proteins of ISGF-3. With all of the sequences available, it is clear that three of these proteins are encoded by members of a previously unrecognized gene family. We suggest that proteins encoded by this gene family serve the function of interpreting the fact that a cell surface receptor has bound its ligand so that specific signal transduction to the nucleus can occur.

Original languageEnglish (US)
Pages (from-to)7840-7843
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume89
Issue number16
StatePublished - 1992
Externally publishedYes

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Interferons
Signal Transduction
Genes
Proteins
Cell Surface Receptors
Organism Cloning
Cytoplasm
Transcription Factors
Complementary DNA
Ligands

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

The proteins of ISGF-3, the interferon α-induced transcriptional activator, define a gene family involved in signal transduction. / Fu, Xin Yuan; Schindler, Chris; Improta, Teresa; Aebersold, Ruedi; Darnell, James E.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 16, 1992, p. 7840-7843.

Research output: Contribution to journalArticle

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