The Public Access Defibrillation (PAD) Trial: Study design and rationale

Joseph P. Ornato, Mary Ann McBurnie, Graham Nichol, Marcel Salive, Myron Weisfeldt, Barbara Riegel, James Christenson, Thomas Therndrup, Mohamud Daya, N. Clay Mann, Brent Shaum, Kimberlee Brown, Kammy Jacobsen, Robert Zalenski, Scott Compton, Robert Dunne, Robert Swor, Robert Welch, LynnMarie Mango, Kristen BilickiMary D. Gunnels, Jerris R. Hedges, Jonathan Jui, Terri Schmidt, Lynn Wittwer, Heather Brooks, Christopher Burke, Denise Griffiths, Lance B. Becker, Anne Barry, Ellen Demertsidies, Michael R. Sayre, Jim Christenson, Sarah Pennington, Allan Holmes, Heather Payne, Roland Webb, Nadia Douglas, Patricia Lawson, Mark C. Henry, Scott Johnson, Edward R. Stapleton, Jonathan VanZile, Michael Ottaway, Robert E. O'Connor, Patricia McGraw, Missy Bollinger, Ross E. Megargel, Stephen Ehrlich, Bruce Haynes, Linda Asbury, Shannon Stephens, Sarah D. McNutt, William Groh, Deb Cordes, Susan J. Bondurant, Max Harry Weil, Michael Osur, Brian MacGavin, Britta Myrin, Ruchir Sehra, Vijayaraghavan Krishnaswami, Thomas Mattioni, Vince N. Mosesso, Brian K. Slater, Venard J. Campbell, David Hostler, Richard A. Craven, Lois A. Bosken, Patricia Burke, Judith Paulsen, Gary Newton, Lynne D. Richardson, Frederick Ehlert, Christopher Freyberg, Neal Richmond, Christopher Shields, Ilene Wilets, Jennifer Holohan, Andy R. Anton, Constance D. Jones, Stephen Yahn, Dennis Rabel, David B. Reed, Lawrence H. Brown, Lisa M. Evans, Brian D. Mahoney, Rachel Knudson-Ballard, Mary Ann Peberdy, Elizabeth Ferry Godburn, Daniel Harker, J. Jerry Overton, Richard O. Cummins, Alidene Doherty, Tom P. Aufderheide, Ronald G. Pirrallo, Lisa Parmenter, Laura Grabowski, Eleanor B. Schron

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The PAD Trial is a prospective, multicenter, randomized clinical study testing whether volunteer, non-medical responders can improve survival from out-of-hospital cardiac arrest (OOH-CA) by using automated external defibrillators (AEDs). These lay volunteers, who have no traditional responsibility to respond to a medical emergency as part of their primary job description, will form part of a comprehensive, integrated community approach to the treatment of OOH-CA. The study is being conducted at 24 field centers in the United States and Canada. Approximately 1000 community units (e.g. apartment or office buildings, gated communities, sports facilities, senior centers, shopping malls, etc.) were randomized to treatment by trained laypersons who will provide either cardiopulmonary resuscitation (CPR) alone or CPR plus use of an AED, while awaiting arrival of the community's emergency medical services responders. The primary endpoint is the number of OOH-CA victims who survive to hospital discharge. Secondary endpoints include neurological status, health-related quality of life (HRQL), cost, and cost-effectiveness. Data collection will last approximately 15 months and is expected to be completed in September 2003.

Original languageEnglish
Pages (from-to)135-147
Number of pages13
JournalResuscitation
Volume56
Issue number2
DOIs
StatePublished - Feb 1 2003

Fingerprint

Out-of-Hospital Cardiac Arrest
Defibrillators
Cardiopulmonary Resuscitation
Volunteers
Senior Centers
Job Description
Emergency Medical Services
Cost-Benefit Analysis
Canada
Sports
Emergencies
Quality of Life
Costs and Cost Analysis
Survival
Therapeutics

Keywords

  • Automated external defibrillator (AED)
  • Cardiopulmonary resuscitation (CPR)
  • Defibrillation
  • Emergency medical services (EMS)
  • Out-of-hospital cardiac arrest (OOH-CA)
  • Ventricular fibrillation (VF)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Nursing(all)

Cite this

Ornato, J. P., McBurnie, M. A., Nichol, G., Salive, M., Weisfeldt, M., Riegel, B., ... Schron, E. B. (2003). The Public Access Defibrillation (PAD) Trial: Study design and rationale. Resuscitation, 56(2), 135-147. https://doi.org/10.1016/S0300-9572(02)00442-2

The Public Access Defibrillation (PAD) Trial : Study design and rationale. / Ornato, Joseph P.; McBurnie, Mary Ann; Nichol, Graham; Salive, Marcel; Weisfeldt, Myron; Riegel, Barbara; Christenson, James; Therndrup, Thomas; Daya, Mohamud; Mann, N. Clay; Shaum, Brent; Brown, Kimberlee; Jacobsen, Kammy; Zalenski, Robert; Compton, Scott; Dunne, Robert; Swor, Robert; Welch, Robert; Mango, LynnMarie; Bilicki, Kristen; Gunnels, Mary D.; Hedges, Jerris R.; Jui, Jonathan; Schmidt, Terri; Wittwer, Lynn; Brooks, Heather; Burke, Christopher; Griffiths, Denise; Becker, Lance B.; Barry, Anne; Demertsidies, Ellen; Sayre, Michael R.; Christenson, Jim; Pennington, Sarah; Holmes, Allan; Payne, Heather; Webb, Roland; Douglas, Nadia; Lawson, Patricia; Henry, Mark C.; Johnson, Scott; Stapleton, Edward R.; VanZile, Jonathan; Ottaway, Michael; O'Connor, Robert E.; McGraw, Patricia; Bollinger, Missy; Megargel, Ross E.; Ehrlich, Stephen; Haynes, Bruce; Asbury, Linda; Stephens, Shannon; McNutt, Sarah D.; Groh, William; Cordes, Deb; Bondurant, Susan J.; Weil, Max Harry; Osur, Michael; MacGavin, Brian; Myrin, Britta; Sehra, Ruchir; Krishnaswami, Vijayaraghavan; Mattioni, Thomas; Mosesso, Vince N.; Slater, Brian K.; Campbell, Venard J.; Hostler, David; Craven, Richard A.; Bosken, Lois A.; Burke, Patricia; Paulsen, Judith; Newton, Gary; Richardson, Lynne D.; Ehlert, Frederick; Freyberg, Christopher; Richmond, Neal; Shields, Christopher; Wilets, Ilene; Holohan, Jennifer; Anton, Andy R.; Jones, Constance D.; Yahn, Stephen; Rabel, Dennis; Reed, David B.; Brown, Lawrence H.; Evans, Lisa M.; Mahoney, Brian D.; Knudson-Ballard, Rachel; Peberdy, Mary Ann; Godburn, Elizabeth Ferry; Harker, Daniel; Overton, J. Jerry; Cummins, Richard O.; Doherty, Alidene; Aufderheide, Tom P.; Pirrallo, Ronald G.; Parmenter, Lisa; Grabowski, Laura; Schron, Eleanor B.

In: Resuscitation, Vol. 56, No. 2, 01.02.2003, p. 135-147.

Research output: Contribution to journalArticle

Ornato, JP, McBurnie, MA, Nichol, G, Salive, M, Weisfeldt, M, Riegel, B, Christenson, J, Therndrup, T, Daya, M, Mann, NC, Shaum, B, Brown, K, Jacobsen, K, Zalenski, R, Compton, S, Dunne, R, Swor, R, Welch, R, Mango, L, Bilicki, K, Gunnels, MD, Hedges, JR, Jui, J, Schmidt, T, Wittwer, L, Brooks, H, Burke, C, Griffiths, D, Becker, LB, Barry, A, Demertsidies, E, Sayre, MR, Christenson, J, Pennington, S, Holmes, A, Payne, H, Webb, R, Douglas, N, Lawson, P, Henry, MC, Johnson, S, Stapleton, ER, VanZile, J, Ottaway, M, O'Connor, RE, McGraw, P, Bollinger, M, Megargel, RE, Ehrlich, S, Haynes, B, Asbury, L, Stephens, S, McNutt, SD, Groh, W, Cordes, D, Bondurant, SJ, Weil, MH, Osur, M, MacGavin, B, Myrin, B, Sehra, R, Krishnaswami, V, Mattioni, T, Mosesso, VN, Slater, BK, Campbell, VJ, Hostler, D, Craven, RA, Bosken, LA, Burke, P, Paulsen, J, Newton, G, Richardson, LD, Ehlert, F, Freyberg, C, Richmond, N, Shields, C, Wilets, I, Holohan, J, Anton, AR, Jones, CD, Yahn, S, Rabel, D, Reed, DB, Brown, LH, Evans, LM, Mahoney, BD, Knudson-Ballard, R, Peberdy, MA, Godburn, EF, Harker, D, Overton, JJ, Cummins, RO, Doherty, A, Aufderheide, TP, Pirrallo, RG, Parmenter, L, Grabowski, L & Schron, EB 2003, 'The Public Access Defibrillation (PAD) Trial: Study design and rationale', Resuscitation, vol. 56, no. 2, pp. 135-147. https://doi.org/10.1016/S0300-9572(02)00442-2
Ornato JP, McBurnie MA, Nichol G, Salive M, Weisfeldt M, Riegel B et al. The Public Access Defibrillation (PAD) Trial: Study design and rationale. Resuscitation. 2003 Feb 1;56(2):135-147. https://doi.org/10.1016/S0300-9572(02)00442-2
Ornato, Joseph P. ; McBurnie, Mary Ann ; Nichol, Graham ; Salive, Marcel ; Weisfeldt, Myron ; Riegel, Barbara ; Christenson, James ; Therndrup, Thomas ; Daya, Mohamud ; Mann, N. Clay ; Shaum, Brent ; Brown, Kimberlee ; Jacobsen, Kammy ; Zalenski, Robert ; Compton, Scott ; Dunne, Robert ; Swor, Robert ; Welch, Robert ; Mango, LynnMarie ; Bilicki, Kristen ; Gunnels, Mary D. ; Hedges, Jerris R. ; Jui, Jonathan ; Schmidt, Terri ; Wittwer, Lynn ; Brooks, Heather ; Burke, Christopher ; Griffiths, Denise ; Becker, Lance B. ; Barry, Anne ; Demertsidies, Ellen ; Sayre, Michael R. ; Christenson, Jim ; Pennington, Sarah ; Holmes, Allan ; Payne, Heather ; Webb, Roland ; Douglas, Nadia ; Lawson, Patricia ; Henry, Mark C. ; Johnson, Scott ; Stapleton, Edward R. ; VanZile, Jonathan ; Ottaway, Michael ; O'Connor, Robert E. ; McGraw, Patricia ; Bollinger, Missy ; Megargel, Ross E. ; Ehrlich, Stephen ; Haynes, Bruce ; Asbury, Linda ; Stephens, Shannon ; McNutt, Sarah D. ; Groh, William ; Cordes, Deb ; Bondurant, Susan J. ; Weil, Max Harry ; Osur, Michael ; MacGavin, Brian ; Myrin, Britta ; Sehra, Ruchir ; Krishnaswami, Vijayaraghavan ; Mattioni, Thomas ; Mosesso, Vince N. ; Slater, Brian K. ; Campbell, Venard J. ; Hostler, David ; Craven, Richard A. ; Bosken, Lois A. ; Burke, Patricia ; Paulsen, Judith ; Newton, Gary ; Richardson, Lynne D. ; Ehlert, Frederick ; Freyberg, Christopher ; Richmond, Neal ; Shields, Christopher ; Wilets, Ilene ; Holohan, Jennifer ; Anton, Andy R. ; Jones, Constance D. ; Yahn, Stephen ; Rabel, Dennis ; Reed, David B. ; Brown, Lawrence H. ; Evans, Lisa M. ; Mahoney, Brian D. ; Knudson-Ballard, Rachel ; Peberdy, Mary Ann ; Godburn, Elizabeth Ferry ; Harker, Daniel ; Overton, J. Jerry ; Cummins, Richard O. ; Doherty, Alidene ; Aufderheide, Tom P. ; Pirrallo, Ronald G. ; Parmenter, Lisa ; Grabowski, Laura ; Schron, Eleanor B. / The Public Access Defibrillation (PAD) Trial : Study design and rationale. In: Resuscitation. 2003 ; Vol. 56, No. 2. pp. 135-147.
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T1 - The Public Access Defibrillation (PAD) Trial

T2 - Study design and rationale

AU - Ornato, Joseph P.

AU - McBurnie, Mary Ann

AU - Nichol, Graham

AU - Salive, Marcel

AU - Weisfeldt, Myron

AU - Riegel, Barbara

AU - Christenson, James

AU - Therndrup, Thomas

AU - Daya, Mohamud

AU - Mann, N. Clay

AU - Shaum, Brent

AU - Brown, Kimberlee

AU - Jacobsen, Kammy

AU - Zalenski, Robert

AU - Compton, Scott

AU - Dunne, Robert

AU - Swor, Robert

AU - Welch, Robert

AU - Mango, LynnMarie

AU - Bilicki, Kristen

AU - Gunnels, Mary D.

AU - Hedges, Jerris R.

AU - Jui, Jonathan

AU - Schmidt, Terri

AU - Wittwer, Lynn

AU - Brooks, Heather

AU - Burke, Christopher

AU - Griffiths, Denise

AU - Becker, Lance B.

AU - Barry, Anne

AU - Demertsidies, Ellen

AU - Sayre, Michael R.

AU - Christenson, Jim

AU - Pennington, Sarah

AU - Holmes, Allan

AU - Payne, Heather

AU - Webb, Roland

AU - Douglas, Nadia

AU - Lawson, Patricia

AU - Henry, Mark C.

AU - Johnson, Scott

AU - Stapleton, Edward R.

AU - VanZile, Jonathan

AU - Ottaway, Michael

AU - O'Connor, Robert E.

AU - McGraw, Patricia

AU - Bollinger, Missy

AU - Megargel, Ross E.

AU - Ehrlich, Stephen

AU - Haynes, Bruce

AU - Asbury, Linda

AU - Stephens, Shannon

AU - McNutt, Sarah D.

AU - Groh, William

AU - Cordes, Deb

AU - Bondurant, Susan J.

AU - Weil, Max Harry

AU - Osur, Michael

AU - MacGavin, Brian

AU - Myrin, Britta

AU - Sehra, Ruchir

AU - Krishnaswami, Vijayaraghavan

AU - Mattioni, Thomas

AU - Mosesso, Vince N.

AU - Slater, Brian K.

AU - Campbell, Venard J.

AU - Hostler, David

AU - Craven, Richard A.

AU - Bosken, Lois A.

AU - Burke, Patricia

AU - Paulsen, Judith

AU - Newton, Gary

AU - Richardson, Lynne D.

AU - Ehlert, Frederick

AU - Freyberg, Christopher

AU - Richmond, Neal

AU - Shields, Christopher

AU - Wilets, Ilene

AU - Holohan, Jennifer

AU - Anton, Andy R.

AU - Jones, Constance D.

AU - Yahn, Stephen

AU - Rabel, Dennis

AU - Reed, David B.

AU - Brown, Lawrence H.

AU - Evans, Lisa M.

AU - Mahoney, Brian D.

AU - Knudson-Ballard, Rachel

AU - Peberdy, Mary Ann

AU - Godburn, Elizabeth Ferry

AU - Harker, Daniel

AU - Overton, J. Jerry

AU - Cummins, Richard O.

AU - Doherty, Alidene

AU - Aufderheide, Tom P.

AU - Pirrallo, Ronald G.

AU - Parmenter, Lisa

AU - Grabowski, Laura

AU - Schron, Eleanor B.

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KW - Cardiopulmonary resuscitation (CPR)

KW - Defibrillation

KW - Emergency medical services (EMS)

KW - Out-of-hospital cardiac arrest (OOH-CA)

KW - Ventricular fibrillation (VF)

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