The Regulation of CD1d+ and CD1d- tumors by NKT cells

Jianyun Liu, Gourapura J. Renukaradhya, Randy Brutkiewicz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Natural killer T (NKT) cells are T cells that also express NK cell -markers. Unlike conventional T cells that recognize peptide antigens, NKT cells recognize lipids. CD1d, a MHC class I-like molecule, presents lipid antigens to NKT cells. Upon activation, NKT cells secrete both Th1 and Th2 cytokines, linking the innate and adaptive immune response. Due to the heterogeneity of NKT cells, their roles in the immune system are mixed and controversial. Here, we summarize the current knowledge of NKT cells as antitumor effector cells, in the control of both CD1d+ and CD1d- tumors as model systems. Overall, NKT cells exhibit a remarkable broad range of antitumor activities and show great potential for antitumor immunotherapy.

Original languageEnglish (US)
Title of host publicationNatural Killer T cells
Subtitle of host publicationBalancing the Regulation of Tumor Immunity
PublisherSpringer New York
Pages71-94
Number of pages24
ISBN (Electronic)9781461406136
ISBN (Print)9781461406129
DOIs
StatePublished - Jan 1 2012

Fingerprint

Natural Killer T-Cells
Neoplasms
T-Lymphocytes
Lipids
Antigens
Adaptive Immunity
Innate Immunity
Natural Killer Cells
Immunotherapy
Immune System
Cytokines
Peptides

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, J., Renukaradhya, G. J., & Brutkiewicz, R. (2012). The Regulation of CD1d+ and CD1d- tumors by NKT cells. In Natural Killer T cells: Balancing the Regulation of Tumor Immunity (pp. 71-94). Springer New York. https://doi.org/10.1007/978-1-4614-0613-6_5

The Regulation of CD1d+ and CD1d- tumors by NKT cells. / Liu, Jianyun; Renukaradhya, Gourapura J.; Brutkiewicz, Randy.

Natural Killer T cells: Balancing the Regulation of Tumor Immunity. Springer New York, 2012. p. 71-94.

Research output: Chapter in Book/Report/Conference proceedingChapter

Liu, J, Renukaradhya, GJ & Brutkiewicz, R 2012, The Regulation of CD1d+ and CD1d- tumors by NKT cells. in Natural Killer T cells: Balancing the Regulation of Tumor Immunity. Springer New York, pp. 71-94. https://doi.org/10.1007/978-1-4614-0613-6_5
Liu J, Renukaradhya GJ, Brutkiewicz R. The Regulation of CD1d+ and CD1d- tumors by NKT cells. In Natural Killer T cells: Balancing the Regulation of Tumor Immunity. Springer New York. 2012. p. 71-94 https://doi.org/10.1007/978-1-4614-0613-6_5
Liu, Jianyun ; Renukaradhya, Gourapura J. ; Brutkiewicz, Randy. / The Regulation of CD1d+ and CD1d- tumors by NKT cells. Natural Killer T cells: Balancing the Regulation of Tumor Immunity. Springer New York, 2012. pp. 71-94
@inbook{90cc6bfaab2849fc9c6672b72c03cdd3,
title = "The Regulation of CD1d+ and CD1d- tumors by NKT cells",
abstract = "Natural killer T (NKT) cells are T cells that also express NK cell -markers. Unlike conventional T cells that recognize peptide antigens, NKT cells recognize lipids. CD1d, a MHC class I-like molecule, presents lipid antigens to NKT cells. Upon activation, NKT cells secrete both Th1 and Th2 cytokines, linking the innate and adaptive immune response. Due to the heterogeneity of NKT cells, their roles in the immune system are mixed and controversial. Here, we summarize the current knowledge of NKT cells as antitumor effector cells, in the control of both CD1d+ and CD1d- tumors as model systems. Overall, NKT cells exhibit a remarkable broad range of antitumor activities and show great potential for antitumor immunotherapy.",
author = "Jianyun Liu and Renukaradhya, {Gourapura J.} and Randy Brutkiewicz",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/978-1-4614-0613-6_5",
language = "English (US)",
isbn = "9781461406129",
pages = "71--94",
booktitle = "Natural Killer T cells",
publisher = "Springer New York",

}

TY - CHAP

T1 - The Regulation of CD1d+ and CD1d- tumors by NKT cells

AU - Liu, Jianyun

AU - Renukaradhya, Gourapura J.

AU - Brutkiewicz, Randy

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Natural killer T (NKT) cells are T cells that also express NK cell -markers. Unlike conventional T cells that recognize peptide antigens, NKT cells recognize lipids. CD1d, a MHC class I-like molecule, presents lipid antigens to NKT cells. Upon activation, NKT cells secrete both Th1 and Th2 cytokines, linking the innate and adaptive immune response. Due to the heterogeneity of NKT cells, their roles in the immune system are mixed and controversial. Here, we summarize the current knowledge of NKT cells as antitumor effector cells, in the control of both CD1d+ and CD1d- tumors as model systems. Overall, NKT cells exhibit a remarkable broad range of antitumor activities and show great potential for antitumor immunotherapy.

AB - Natural killer T (NKT) cells are T cells that also express NK cell -markers. Unlike conventional T cells that recognize peptide antigens, NKT cells recognize lipids. CD1d, a MHC class I-like molecule, presents lipid antigens to NKT cells. Upon activation, NKT cells secrete both Th1 and Th2 cytokines, linking the innate and adaptive immune response. Due to the heterogeneity of NKT cells, their roles in the immune system are mixed and controversial. Here, we summarize the current knowledge of NKT cells as antitumor effector cells, in the control of both CD1d+ and CD1d- tumors as model systems. Overall, NKT cells exhibit a remarkable broad range of antitumor activities and show great potential for antitumor immunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=84862492848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862492848&partnerID=8YFLogxK

U2 - 10.1007/978-1-4614-0613-6_5

DO - 10.1007/978-1-4614-0613-6_5

M3 - Chapter

SN - 9781461406129

SP - 71

EP - 94

BT - Natural Killer T cells

PB - Springer New York

ER -