The Regulation of CD1d+ and CD1d- tumors by NKT cells

Jianyun Liu, Gourapura J. Renukaradhya, Randy R. Brutkiewicz

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Natural killer T (NKT) cells are T cells that also express NK cell -markers. Unlike conventional T cells that recognize peptide antigens, NKT cells recognize lipids. CD1d, a MHC class I-like molecule, presents lipid antigens to NKT cells. Upon activation, NKT cells secrete both Th1 and Th2 cytokines, linking the innate and adaptive immune response. Due to the heterogeneity of NKT cells, their roles in the immune system are mixed and controversial. Here, we summarize the current knowledge of NKT cells as antitumor effector cells, in the control of both CD1d+ and CD1d- tumors as model systems. Overall, NKT cells exhibit a remarkable broad range of antitumor activities and show great potential for antitumor immunotherapy.

Original languageEnglish (US)
Title of host publicationNatural Killer T cells
Subtitle of host publicationBalancing the Regulation of Tumor Immunity
PublisherSpringer New York
Pages71-94
Number of pages24
ISBN (Electronic)9781461406136
ISBN (Print)9781461406129
DOIs
StatePublished - Jan 1 2012

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Liu, J., Renukaradhya, G. J., & Brutkiewicz, R. R. (2012). The Regulation of CD1d+ and CD1d- tumors by NKT cells. In Natural Killer T cells: Balancing the Regulation of Tumor Immunity (pp. 71-94). Springer New York. https://doi.org/10.1007/978-1-4614-0613-6_5