The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors

Zheng Ming Ding, Cynthia M. Ingraham, Zachary Rodd, William J. McBride

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Ethanol is reinforcing within the nucleus accumbens shell (NACsh), but the underlying mechanisms remain unclear. Ethanol can potentiate the function of the GABAA, GABAB, and serotonin-3 (5-HT3) receptors. Therefore, the current study tested the hypothesis that activation of these receptors would be involved in the reinforcing effects of ethanol in the NACsh. An intracranial self-administration (ICSA) procedure was used to assess the reinforcing effects of ethanol in the NACsh of alcohol preferring (P) rats. The ICSA consisted of seven sessions: four sessions to establish 150 mg% ethanol self-infusion into the NACsh; sessions 5 and 6 with co-infusion of ethanol plus one concentration of the GABAA antagonist bicuculline (10 or 100 μM), the GABAB antagonist SCH 50911 (50, 75 or 100 μM), or the 5-HT3 receptor antagonist zacopride (10 or 100 μM); and session 7 with 150 mg% ethanol alone. All groups self-infused ethanol into the NACsh and readily discriminated the active from inactive lever during the acquisition sessions. Co-infusion of 100 μM, but not 10 μM, bicuculline or zacopride significantly decreased active responses during sessions 5 and 6. Co-infusion of 75 μM, but not 50 or 100 μM, SCH 50911 significantly attenuated responses for ethanol. Overall, the results suggest that the reinforcing effects of ethanol in the NACsh may be modulated by activation of local GABAA, GABAB and 5-HT3 receptors.

Original languageEnglish
Pages (from-to)725-733
Number of pages9
JournalJournal of Psychopharmacology
Volume29
Issue number6
DOIs
StatePublished - Jun 6 2015

Fingerprint

GABA Receptors
Serotonin Receptors
Nucleus Accumbens
Ethanol
Receptors, Serotonin, 5-HT3
Self Administration
Bicuculline
Serotonin 5-HT3 Receptor Antagonists
GABA-A Receptor Antagonists
Alcohols

Keywords

  • ethanol
  • GABAA receptor
  • GABAB receptor
  • Intracranial self-administration
  • nucleus accumbens
  • serotonin receptor

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Psychiatry and Mental health

Cite this

The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. / Ding, Zheng Ming; Ingraham, Cynthia M.; Rodd, Zachary; McBride, William J.

In: Journal of Psychopharmacology, Vol. 29, No. 6, 06.06.2015, p. 725-733.

Research output: Contribution to journalArticle

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