The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia

Joshua M. Diamond, Mary K. Porteous, L. Jackson Roberts, Nancy Wickersham, Melanie Rushefski, Steven M. Kawut, Rupal J. Shah, Edward Cantu, David J. Lederer, Shampa Chatterjee, Vibha N. Lama, Sangeeta Bhorade, Maria Crespo, John McDyer, Keith Wille, Jonathan Orens, Ann Weinacker, Selim Arcasoy, Pali D. Shah, David S. Wilkes & 6 others Chadi Hage, Scott M. Palmer, Laurie Snyder, Carolyn S. Calfee, Lorraine B. Ware, Jason D. Christie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background Donor smoking history and higher fraction of inspired oxygen (Fio2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigarette smoke and recipient hyperoxia at reperfusion. Methods We performed a nested case-control study of 72 lung transplant recipients from the Lung Transplant Outcomes Group cohort. Using mass spectroscopy, F2-isoprostanes and isofurans were measured in plasma collected after transplantation. Cases were defined in 2 ways: grade 3 PGD present at day 2 or day 3 after reperfusion (severe PGD) or any grade 3 PGD (any PGD). Results There were 31 severe PGD cases with 41 controls and 35 any PGD cases with 37 controls. Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (28.6 pg/ml vs 19.8 pg/ml, p = 0.03). Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (29.6 pg/ml vs 19.0 pg/ml, p = 0.03) among patients reperfused with Fio2 >40%. Among recipients of lungs from donors with smoke exposure, plasma F2-isoprostane (38.2 pg/ml vs 22.5 pg/ml, p = 0.046) and isofuran (66.9 pg/ml vs 34.6 pg/ml, p = 0.046) levels were higher in severe PGD compared with control subjects. Conclusions Plasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia at reperfusion.

Original languageEnglish (US)
Pages (from-to)500-507
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume35
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Primary Graft Dysfunction
Hyperoxia
Lung Transplantation
Lipid Peroxidation
Reperfusion
Smoking
Tissue Donors
F2-Isoprostanes
Smoke
Lung
Tobacco Products
Prostaglandins D
Wounds and Injuries

Keywords

  • F2-isoprostane
  • ischemia reperfusion
  • isofuran
  • lipid peroxidation
  • lung transplantation
  • primary graft dysfunction

ASJC Scopus subject areas

  • Transplantation
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Surgery

Cite this

The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. / Diamond, Joshua M.; Porteous, Mary K.; Jackson Roberts, L.; Wickersham, Nancy; Rushefski, Melanie; Kawut, Steven M.; Shah, Rupal J.; Cantu, Edward; Lederer, David J.; Chatterjee, Shampa; Lama, Vibha N.; Bhorade, Sangeeta; Crespo, Maria; McDyer, John; Wille, Keith; Orens, Jonathan; Weinacker, Ann; Arcasoy, Selim; Shah, Pali D.; Wilkes, David S.; Hage, Chadi; Palmer, Scott M.; Snyder, Laurie; Calfee, Carolyn S.; Ware, Lorraine B.; Christie, Jason D.

In: Journal of Heart and Lung Transplantation, Vol. 35, No. 4, 01.04.2016, p. 500-507.

Research output: Contribution to journalArticle

Diamond, JM, Porteous, MK, Jackson Roberts, L, Wickersham, N, Rushefski, M, Kawut, SM, Shah, RJ, Cantu, E, Lederer, DJ, Chatterjee, S, Lama, VN, Bhorade, S, Crespo, M, McDyer, J, Wille, K, Orens, J, Weinacker, A, Arcasoy, S, Shah, PD, Wilkes, DS, Hage, C, Palmer, SM, Snyder, L, Calfee, CS, Ware, LB & Christie, JD 2016, 'The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia', Journal of Heart and Lung Transplantation, vol. 35, no. 4, pp. 500-507. https://doi.org/10.1016/j.healun.2015.12.012
Diamond, Joshua M. ; Porteous, Mary K. ; Jackson Roberts, L. ; Wickersham, Nancy ; Rushefski, Melanie ; Kawut, Steven M. ; Shah, Rupal J. ; Cantu, Edward ; Lederer, David J. ; Chatterjee, Shampa ; Lama, Vibha N. ; Bhorade, Sangeeta ; Crespo, Maria ; McDyer, John ; Wille, Keith ; Orens, Jonathan ; Weinacker, Ann ; Arcasoy, Selim ; Shah, Pali D. ; Wilkes, David S. ; Hage, Chadi ; Palmer, Scott M. ; Snyder, Laurie ; Calfee, Carolyn S. ; Ware, Lorraine B. ; Christie, Jason D. / The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia. In: Journal of Heart and Lung Transplantation. 2016 ; Vol. 35, No. 4. pp. 500-507.
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abstract = "Background Donor smoking history and higher fraction of inspired oxygen (Fio2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigarette smoke and recipient hyperoxia at reperfusion. Methods We performed a nested case-control study of 72 lung transplant recipients from the Lung Transplant Outcomes Group cohort. Using mass spectroscopy, F2-isoprostanes and isofurans were measured in plasma collected after transplantation. Cases were defined in 2 ways: grade 3 PGD present at day 2 or day 3 after reperfusion (severe PGD) or any grade 3 PGD (any PGD). Results There were 31 severe PGD cases with 41 controls and 35 any PGD cases with 37 controls. Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (28.6 pg/ml vs 19.8 pg/ml, p = 0.03). Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (29.6 pg/ml vs 19.0 pg/ml, p = 0.03) among patients reperfused with Fio2 >40{\%}. Among recipients of lungs from donors with smoke exposure, plasma F2-isoprostane (38.2 pg/ml vs 22.5 pg/ml, p = 0.046) and isofuran (66.9 pg/ml vs 34.6 pg/ml, p = 0.046) levels were higher in severe PGD compared with control subjects. Conclusions Plasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia at reperfusion.",
keywords = "F2-isoprostane, ischemia reperfusion, isofuran, lipid peroxidation, lung transplantation, primary graft dysfunction",
author = "Diamond, {Joshua M.} and Porteous, {Mary K.} and {Jackson Roberts}, L. and Nancy Wickersham and Melanie Rushefski and Kawut, {Steven M.} and Shah, {Rupal J.} and Edward Cantu and Lederer, {David J.} and Shampa Chatterjee and Lama, {Vibha N.} and Sangeeta Bhorade and Maria Crespo and John McDyer and Keith Wille and Jonathan Orens and Ann Weinacker and Selim Arcasoy and Shah, {Pali D.} and Wilkes, {David S.} and Chadi Hage and Palmer, {Scott M.} and Laurie Snyder and Calfee, {Carolyn S.} and Ware, {Lorraine B.} and Christie, {Jason D.}",
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T1 - The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia

AU - Diamond, Joshua M.

AU - Porteous, Mary K.

AU - Jackson Roberts, L.

AU - Wickersham, Nancy

AU - Rushefski, Melanie

AU - Kawut, Steven M.

AU - Shah, Rupal J.

AU - Cantu, Edward

AU - Lederer, David J.

AU - Chatterjee, Shampa

AU - Lama, Vibha N.

AU - Bhorade, Sangeeta

AU - Crespo, Maria

AU - McDyer, John

AU - Wille, Keith

AU - Orens, Jonathan

AU - Weinacker, Ann

AU - Arcasoy, Selim

AU - Shah, Pali D.

AU - Wilkes, David S.

AU - Hage, Chadi

AU - Palmer, Scott M.

AU - Snyder, Laurie

AU - Calfee, Carolyn S.

AU - Ware, Lorraine B.

AU - Christie, Jason D.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background Donor smoking history and higher fraction of inspired oxygen (Fio2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigarette smoke and recipient hyperoxia at reperfusion. Methods We performed a nested case-control study of 72 lung transplant recipients from the Lung Transplant Outcomes Group cohort. Using mass spectroscopy, F2-isoprostanes and isofurans were measured in plasma collected after transplantation. Cases were defined in 2 ways: grade 3 PGD present at day 2 or day 3 after reperfusion (severe PGD) or any grade 3 PGD (any PGD). Results There were 31 severe PGD cases with 41 controls and 35 any PGD cases with 37 controls. Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (28.6 pg/ml vs 19.8 pg/ml, p = 0.03). Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (29.6 pg/ml vs 19.0 pg/ml, p = 0.03) among patients reperfused with Fio2 >40%. Among recipients of lungs from donors with smoke exposure, plasma F2-isoprostane (38.2 pg/ml vs 22.5 pg/ml, p = 0.046) and isofuran (66.9 pg/ml vs 34.6 pg/ml, p = 0.046) levels were higher in severe PGD compared with control subjects. Conclusions Plasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia at reperfusion.

AB - Background Donor smoking history and higher fraction of inspired oxygen (Fio2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with higher levels associated with donor exposure to cigarette smoke and recipient hyperoxia at reperfusion. Methods We performed a nested case-control study of 72 lung transplant recipients from the Lung Transplant Outcomes Group cohort. Using mass spectroscopy, F2-isoprostanes and isofurans were measured in plasma collected after transplantation. Cases were defined in 2 ways: grade 3 PGD present at day 2 or day 3 after reperfusion (severe PGD) or any grade 3 PGD (any PGD). Results There were 31 severe PGD cases with 41 controls and 35 any PGD cases with 37 controls. Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (28.6 pg/ml vs 19.8 pg/ml, p = 0.03). Plasma F2-isoprostane levels were higher in severe PGD cases compared with controls (29.6 pg/ml vs 19.0 pg/ml, p = 0.03) among patients reperfused with Fio2 >40%. Among recipients of lungs from donors with smoke exposure, plasma F2-isoprostane (38.2 pg/ml vs 22.5 pg/ml, p = 0.046) and isofuran (66.9 pg/ml vs 34.6 pg/ml, p = 0.046) levels were higher in severe PGD compared with control subjects. Conclusions Plasma levels of lipid peroxidation products are higher in patients with severe PGD, in recipients of lungs from donors with smoke exposure, and in recipients exposed to higher Fio2 at reperfusion. Oxidative injury is an important mechanism of PGD and may be magnified by donor exposure to cigarette smoke and hyperoxia at reperfusion.

KW - F2-isoprostane

KW - ischemia reperfusion

KW - isofuran

KW - lipid peroxidation

KW - lung transplantation

KW - primary graft dysfunction

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