The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens

Rebecca A. Marks, Michael Koch, Antonio Lopez-Beltran, Rodolfo Montironi, Beth E. Juliar, Liang Cheng

Research output: Contribution to journalArticle

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Abstract

The presence of positive surgical margins is a negative prognostic indicator in patients undergoing prostatectomy for prostate cancer; whether the extent of the positive margins affects the clinical outcome with regards to prostate-specific antigen (PSA) recurrence remains uncertain. We evaluated the linear extent of margin positivity as a prognostic indicator in a series of radical prostatectomy specimens. One hundred seventy-four consecutive margin-positive prostatectomy specimens were evaluated. The linear extent of margin positivity was measured with an ocular micrometer and ranged from 0.05 to 75.0 mm (mean, 8.94; median, 5.0). The linear extent of margin positivity was associated with tumor volume (P = .03) but was not associated with patients' age at surgery, preoperative PSA level, prostate weight, pathologic stage, Gleason score, extraprostatic extension, seminal vesicle invasion, perineural invasion, high-grade prostatic intraepithelial neoplasia, or PSA recurrence. In the full model multiple Cox regression, significant predictors for PSA recurrence were Gleason score (P = .001) and preoperative PSA (P = .01); extent of margin positivity was not predictive of PSA recurrence (hazard ratio, 1.00; 95% confidence interval, 0.98-1.02; P = .97) nor was tumor volume a significant factor when adjusted for other covariates (P = .27). Preoperative PSA, tumor stage, and Gleason score remained significant prognostic factors in evaluating the likelihood of PSA recurrence in patients with positive surgical margins; the extent of margin positivity, however, is not a prognostic factor for PSA recurrence and should, therefore, not necessarily be included in the final report for radical prostatectomy specimens.

Original languageEnglish
Pages (from-to)1207-1211
Number of pages5
JournalHuman Pathology
Volume38
Issue number8
DOIs
StatePublished - Aug 2007

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Prostate-Specific Antigen
Prostatectomy
Recurrence
Neoplasm Grading
Tumor Burden
Prostatic Intraepithelial Neoplasia
Margins of Excision
Seminal Vesicles
Proportional Hazards Models
Prostate
Prostatic Neoplasms
Confidence Intervals
Weights and Measures

Keywords

  • Adenocarcinoma
  • Positive margin
  • Prostatic neoplasm
  • Radical prostatectomy
  • Staging
  • Surgical margins
  • Tumor volume

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens. / Marks, Rebecca A.; Koch, Michael; Lopez-Beltran, Antonio; Montironi, Rodolfo; Juliar, Beth E.; Cheng, Liang.

In: Human Pathology, Vol. 38, No. 8, 08.2007, p. 1207-1211.

Research output: Contribution to journalArticle

Marks, Rebecca A. ; Koch, Michael ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Juliar, Beth E. ; Cheng, Liang. / The relationship between the extent of surgical margin positivity and prostate specific antigen recurrence in radical prostatectomy specimens. In: Human Pathology. 2007 ; Vol. 38, No. 8. pp. 1207-1211.
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