The relationship of macular microcirculation to visual acuity in diabetic patients

O. Arend, S. Wolf, Alon Harris, M. Reim

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

Objective: To assess the perifoveal microcirculation in diabetic maculopathy without clinically significant macular edema and its relationship to visual acuity. Design: Prospective analysis. Setting: A teaching hospital. Patients: Fifteen patients with impaired visual acuity of 20/50 or worse, a diabetic control population with unaffected visual acuity (matched age, gender, retinopathy stage), and 52 healthy controls were enrolled. Interventions: Study consisted of video-fluorescein angiography with image analyses and hemoglobin A(1c) measurements. Main Outcome Measures: Macular capillary blood velocity, capillary density (perifoveal intercapillary area), and foveal avascular zone. Results: The capillary blood velocity was significantly reduced in both diabetic groups (P2=.51) and perifoveal intercapillary area (R2=.24), indicating an association between enlargement and declined visual acuity. Conclusions: Capillary blood velocity remained unchanged regardless of presence of visual impairment, whereas foveal avascular zone and perifoveal intercapillary area indicated ischemia. This may help in defining a critical hypoxic threshold for visual loss and identifying the presence of an ischemic diabetic maculopathy.

Original languageEnglish (US)
Pages (from-to)610-614
Number of pages5
JournalArchives of Ophthalmology
Volume113
Issue number5
StatePublished - 1995

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Microcirculation
Visual Acuity
Hemoglobin A
Macular Edema
Fluorescein Angiography
Vision Disorders
Teaching Hospitals
Ischemia
Outcome Assessment (Health Care)
Population

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The relationship of macular microcirculation to visual acuity in diabetic patients. / Arend, O.; Wolf, S.; Harris, Alon; Reim, M.

In: Archives of Ophthalmology, Vol. 113, No. 5, 1995, p. 610-614.

Research output: Contribution to journalArticle

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