The renal sodium-calcium exchanger

Jesus Dominguez, Magdalena Juhaszova, Hilary A. Feister

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The functional expression of the renal sodium-calcium exchanger has been amply documented in studies on renal cortical basolateral membranes. In perfused renal tubules, other investigators have shown sodium-calcium exchange activity in the proximal convolution of the rat and in the distal convolution, the connecting tubule, and the collecting tubule of the rabbit. In rat proximal tubules, we found that the sodium-calcium exchanger is an Important determinant of cytosolic calcium homeostasis, since inhibition of sodium-dependent calcium efflux mode caused a large accumulation of tubular calcium. In membranes from rat proximal tubules sodium-calcium activity was high, and in intact proximal tubules, the tubular sodium-calcium exchanger exhibited a high affinity for cytosolic calcium and had a substantial transport capacity, which may be absolute requirements for the maintenance of stable cytosolic calcium in proximal tubules.

Original languageEnglish
Pages (from-to)640-649
Number of pages10
JournalJournal of Laboratory and Clinical Medicine
Volume119
Issue number6
StatePublished - 1992

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Sodium-Calcium Exchanger
Calcium
Kidney
Rats
Sodium
Convolution
Membranes
Homeostasis
Maintenance
Research Personnel
Rabbits

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

Cite this

Dominguez, J., Juhaszova, M., & Feister, H. A. (1992). The renal sodium-calcium exchanger. Journal of Laboratory and Clinical Medicine, 119(6), 640-649.

The renal sodium-calcium exchanger. / Dominguez, Jesus; Juhaszova, Magdalena; Feister, Hilary A.

In: Journal of Laboratory and Clinical Medicine, Vol. 119, No. 6, 1992, p. 640-649.

Research output: Contribution to journalArticle

Dominguez, J, Juhaszova, M & Feister, HA 1992, 'The renal sodium-calcium exchanger', Journal of Laboratory and Clinical Medicine, vol. 119, no. 6, pp. 640-649.
Dominguez, Jesus ; Juhaszova, Magdalena ; Feister, Hilary A. / The renal sodium-calcium exchanger. In: Journal of Laboratory and Clinical Medicine. 1992 ; Vol. 119, No. 6. pp. 640-649.
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