The renin-angiotensin system in aminoglycoside-induced acute renal failure

F. C. Luft, G. R. Aronoff, Andrew Evan, B. A. Connors, M. H. Weinberger, S. A. Kleit

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To examine the role of the renin-angiotensin system in aminoglycoside-induced acute renal failure, we gave rats gentamicin (80 mg/kg/day), gentamicin + captopril (an angiotensin-converting enzyme inhibitor), captopril alone or saline sham injections, for 10 days. Blood pressure, sodium excretion, urine osmolality and creatinine clearance were measured four times during treatment. Plasmin renin activity, angiotensin I-converting enzyme and renal histology were determined at sacrifice. Although angiotensin I-converting enzyme activity was markedly suppressed by captopril treatment, the addition of captopril failed to consistently influence blood pressure or urine osmolality. In addition, it did not promote natriuresis in the face of gentamicin toxicity. Creatinine clearance decreased progressively in groups receiving gentamicin and was lowest (P < .05) in the groups receiving gentamicin + captopril. Captopril did not prevent the development of tubular epithelial nor glomerular endothelial changes associated with gentamicin toxicity. In a separate experiment rats received captopril for 3 days prior, before receiving the gentamicin + captopril regimen for 10 days. Captopril pretreatment did not influence the results. This study does not support a pivotal role for the renin-angiotensin system in the production of the decreased glomerular filtration rate observed in nephrotoxic acute renal failure induced by gentamicin in rats.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalJournal of Pharmacology and Experimental Therapeutics
Volume220
Issue number2
StatePublished - 1982

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Captopril
Aminoglycosides
Renin-Angiotensin System
Acute Kidney Injury
Gentamicins
Peptidyl-Dipeptidase A
Osmolar Concentration
Creatinine
Urine
Blood Pressure
Natriuresis
Fibrinolysin
Glomerular Filtration Rate
Angiotensin-Converting Enzyme Inhibitors
Renin
Histology
Sodium
Kidney
Injections
Therapeutics

ASJC Scopus subject areas

  • Pharmacology

Cite this

Luft, F. C., Aronoff, G. R., Evan, A., Connors, B. A., Weinberger, M. H., & Kleit, S. A. (1982). The renin-angiotensin system in aminoglycoside-induced acute renal failure. Journal of Pharmacology and Experimental Therapeutics, 220(2), 433-439.

The renin-angiotensin system in aminoglycoside-induced acute renal failure. / Luft, F. C.; Aronoff, G. R.; Evan, Andrew; Connors, B. A.; Weinberger, M. H.; Kleit, S. A.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 220, No. 2, 1982, p. 433-439.

Research output: Contribution to journalArticle

Luft, FC, Aronoff, GR, Evan, A, Connors, BA, Weinberger, MH & Kleit, SA 1982, 'The renin-angiotensin system in aminoglycoside-induced acute renal failure', Journal of Pharmacology and Experimental Therapeutics, vol. 220, no. 2, pp. 433-439.
Luft, F. C. ; Aronoff, G. R. ; Evan, Andrew ; Connors, B. A. ; Weinberger, M. H. ; Kleit, S. A. / The renin-angiotensin system in aminoglycoside-induced acute renal failure. In: Journal of Pharmacology and Experimental Therapeutics. 1982 ; Vol. 220, No. 2. pp. 433-439.
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