The response of rubrospinal neurons to axotomy in the adult opossum, didelphis virginiana

Xiao Ming Xu, George F. Martin

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

To provide endpoints for developmental studies of rubrospinal plasticity in the North American opossum, we have attempted to determine the degree to which rubrospinal neurons survive axotomy in the adult animal. Bilateral or unilateral injections of the long-lasting fluorescent marker fast blue were made into the T-10 or the T-11 segment of the spinal cord to label rubrospinal neurons, and 7 days later, the rubrospinal tract was cut unilaterally four segments rostral to the injection(s). In cases with unilateral injections, the lesion was made ipsilateral to the injection. The animals were allowed to survive for 30-60 days before being sacrificed and perfused so that sections through the red nuclei could be examined for labeled neurons. The results show that most axotomized neurons survived the lesion, suggesting that lesion-dependent cell death is not a major factor in the failure of the rubrospinal tract to regenerate in the adult animal.

Original languageEnglish (US)
Pages (from-to)46-54
Number of pages9
JournalExperimental Neurology
Volume108
Issue number1
DOIs
StatePublished - Apr 1990
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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