The Right Heart and Its Distinct Mechanisms of Development, Function, and Failure

Troy A. Markel, George M. Wairiuko, Tim Lahm, Paul R. Crisostomo, Meijing Wang, Christine M. Herring, Daniel R. Meldrum

Research output: Contribution to journalReview article

19 Scopus citations

Abstract

Congestive heart failure is the most common cause of hospitalization in the United States for people over the age of sixty-five. As the population ages, the morbidity and mortality from heart failure will become more prevalent. Left heart failure has been, and continues to be, extensively studied. However, a recent report from the National Heart, Lung, and Blood Institute suggests that the right heart has been relatively under-investigated, and unfortunately, most of the basic mechanisms of intracellular signaling within the right heart still remain poorly understood. Right heart failure is now being increasingly recognized as distinctly different from left heart failure, and an important mediator of overall cardiovascular collapse. The purpose of this review, therefore, is to discuss the current understanding of right heart cellular development, physiology, and pathophysiology, as well as to review therapeutic interventions that are both currently available and under investigation.

Original languageEnglish (US)
Pages (from-to)304-313
Number of pages10
JournalJournal of Surgical Research
Volume146
Issue number2
DOIs
StatePublished - May 15 2008

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Keywords

  • endotoxic shock
  • pulmonary hypertension
  • right heart failure
  • right ventricular assist device
  • stem cell therapy
  • transplantation

ASJC Scopus subject areas

  • Surgery

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