The Role of Aspirin, Vitamin D, Exercise, Diet, Statins, and Metformin in the Prevention and Treatment of Colorectal Cancer

Amikar Sehdev, Bert H. O’Neil

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Colorectal cancer (CRC) is a worldwide health problem leading to significant morbidity and mortality. Several strategies based on either lifestyle modifications or pharmacological interventions have been developed in an attempt to reduce the risk of CRC. In this review article, we discuss these interventions including aspirin (and other non-steroidal anti-inflammatory drugs), vitamin D, exercise, diet, statins, and metformin. Depending upon the risk of developing CRC, the current evidence supports the beneficial role of aspirin, vitamin D, diet, and exercise especially in high-risk individuals (advanced adenoma or CRC). However, even with these established interventions, there are significant knowledge gaps such as doses of aspirin and 25-hydroxy vitamin D are not well established. Similarly, there is no convincing data from randomized controlled trials that a high fiber diet or a low animal fat diet reduces the risk of CRC. Some potential interventions, such as statins and metformin, do not have convincing data for clinical use even in high-risk individuals. However, these may have emerging roles in the prevention and treatment of CRC. Greater understanding of molecular mechanisms and the application of genomic tools to risk stratify an individual and tailor the interventions based on that individual’s risk will help further advance the field. Some of this work is already underway and is a focus of this article.

Original languageEnglish (US)
Article number43
JournalCurrent Treatment Options in Oncology
Volume16
Issue number9
DOIs
StatePublished - Sep 28 2015

Fingerprint

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Metformin
Vitamin D
Aspirin
Colorectal Neoplasms
Diet
Therapeutics
Fat-Restricted Diet
Adenoma
Life Style
Anti-Inflammatory Agents
Randomized Controlled Trials
Pharmacology
Morbidity
Mortality
Pharmaceutical Preparations

Keywords

  • Aspirin
  • Celecoxib
  • Colorectal cancer
  • Diet
  • Metformin
  • NSAIDS
  • Physical activity
  • Statins
  • Vitamin D

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)
  • Medicine(all)

Cite this

@article{cd292881861f43a18f2ad1867df9bae0,
title = "The Role of Aspirin, Vitamin D, Exercise, Diet, Statins, and Metformin in the Prevention and Treatment of Colorectal Cancer",
abstract = "Colorectal cancer (CRC) is a worldwide health problem leading to significant morbidity and mortality. Several strategies based on either lifestyle modifications or pharmacological interventions have been developed in an attempt to reduce the risk of CRC. In this review article, we discuss these interventions including aspirin (and other non-steroidal anti-inflammatory drugs), vitamin D, exercise, diet, statins, and metformin. Depending upon the risk of developing CRC, the current evidence supports the beneficial role of aspirin, vitamin D, diet, and exercise especially in high-risk individuals (advanced adenoma or CRC). However, even with these established interventions, there are significant knowledge gaps such as doses of aspirin and 25-hydroxy vitamin D are not well established. Similarly, there is no convincing data from randomized controlled trials that a high fiber diet or a low animal fat diet reduces the risk of CRC. Some potential interventions, such as statins and metformin, do not have convincing data for clinical use even in high-risk individuals. However, these may have emerging roles in the prevention and treatment of CRC. Greater understanding of molecular mechanisms and the application of genomic tools to risk stratify an individual and tailor the interventions based on that individual’s risk will help further advance the field. Some of this work is already underway and is a focus of this article.",
keywords = "Aspirin, Celecoxib, Colorectal cancer, Diet, Metformin, NSAIDS, Physical activity, Statins, Vitamin D",
author = "Amikar Sehdev and O’Neil, {Bert H.}",
year = "2015",
month = "9",
day = "28",
doi = "10.1007/s11864-015-0359-z",
language = "English (US)",
volume = "16",
journal = "Current Treatment Options in Oncology",
issn = "1527-2729",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - The Role of Aspirin, Vitamin D, Exercise, Diet, Statins, and Metformin in the Prevention and Treatment of Colorectal Cancer

AU - Sehdev, Amikar

AU - O’Neil, Bert H.

PY - 2015/9/28

Y1 - 2015/9/28

N2 - Colorectal cancer (CRC) is a worldwide health problem leading to significant morbidity and mortality. Several strategies based on either lifestyle modifications or pharmacological interventions have been developed in an attempt to reduce the risk of CRC. In this review article, we discuss these interventions including aspirin (and other non-steroidal anti-inflammatory drugs), vitamin D, exercise, diet, statins, and metformin. Depending upon the risk of developing CRC, the current evidence supports the beneficial role of aspirin, vitamin D, diet, and exercise especially in high-risk individuals (advanced adenoma or CRC). However, even with these established interventions, there are significant knowledge gaps such as doses of aspirin and 25-hydroxy vitamin D are not well established. Similarly, there is no convincing data from randomized controlled trials that a high fiber diet or a low animal fat diet reduces the risk of CRC. Some potential interventions, such as statins and metformin, do not have convincing data for clinical use even in high-risk individuals. However, these may have emerging roles in the prevention and treatment of CRC. Greater understanding of molecular mechanisms and the application of genomic tools to risk stratify an individual and tailor the interventions based on that individual’s risk will help further advance the field. Some of this work is already underway and is a focus of this article.

AB - Colorectal cancer (CRC) is a worldwide health problem leading to significant morbidity and mortality. Several strategies based on either lifestyle modifications or pharmacological interventions have been developed in an attempt to reduce the risk of CRC. In this review article, we discuss these interventions including aspirin (and other non-steroidal anti-inflammatory drugs), vitamin D, exercise, diet, statins, and metformin. Depending upon the risk of developing CRC, the current evidence supports the beneficial role of aspirin, vitamin D, diet, and exercise especially in high-risk individuals (advanced adenoma or CRC). However, even with these established interventions, there are significant knowledge gaps such as doses of aspirin and 25-hydroxy vitamin D are not well established. Similarly, there is no convincing data from randomized controlled trials that a high fiber diet or a low animal fat diet reduces the risk of CRC. Some potential interventions, such as statins and metformin, do not have convincing data for clinical use even in high-risk individuals. However, these may have emerging roles in the prevention and treatment of CRC. Greater understanding of molecular mechanisms and the application of genomic tools to risk stratify an individual and tailor the interventions based on that individual’s risk will help further advance the field. Some of this work is already underway and is a focus of this article.

KW - Aspirin

KW - Celecoxib

KW - Colorectal cancer

KW - Diet

KW - Metformin

KW - NSAIDS

KW - Physical activity

KW - Statins

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=84938081688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938081688&partnerID=8YFLogxK

U2 - 10.1007/s11864-015-0359-z

DO - 10.1007/s11864-015-0359-z

M3 - Article

VL - 16

JO - Current Treatment Options in Oncology

JF - Current Treatment Options in Oncology

SN - 1527-2729

IS - 9

M1 - 43

ER -