The role of autoimmunity in obliterative bronchiolitis after lung transplantation

Daniel J. Weber, David S. Wilkes

Research output: Contribution to journalReview article

31 Scopus citations

Abstract

First performed in the 1960s with long-term successes achieved in the 1980s, lung transplantation remains the only definitive treatment option for end-stage lung disease. Chronic lung rejection, pathologically classified as obliterative bronchiolitis (OB) with its clinical correlate referred to as bronchiolitis obliterans syndrome, is the limiting factor than keeps 5-yr survival rates for lung transplant significantly worse than for other solid organ transplants. Initially, OB was largely attributed to immune responses to donor antigens, alloimmunity. However, more recent work has demonstrated the role of autoimmunity in the process of lung transplant rejection. IL-17 and autoantigens such as collagen type V and K-α1 tubulin have been implicated in the development of chronic rejection. Ultimately, this translational review discusses the role that autoimmunity plays in the development of OB and lung transplant rejection and then discusses options for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)L307-L311
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume304
Issue number5
DOIs
StatePublished - Mar 11 2013

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Keywords

  • Autoimmunity
  • Lung transplantation
  • Obliterative bronchiolitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology
  • Physiology

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