The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

Charalampia Kyriakou, Sean Molloy, Frank Vrionis, Ronald Alberico, Leonard Bastian, Jeffrey A. Zonder, Sergio Giralt, Noopur Raje, Robert A. Kyle, G. David Roodman, Meletios A. Dimopoulos, S. Vincent Rajkumar, Brian B.G. Durie, Evangelos Terpos

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs.

Original languageEnglish (US)
Article number27
JournalBlood Cancer Journal
Volume9
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Kyphoplasty
Compression Fractures
Multiple Myeloma
Consensus
Pain
Spinal Diseases
Vertebroplasty
Morbidity
Therapeutics
Osteolysis
Hematologic Neoplasms
Early Diagnosis
Survival Rate
Quality of Life
Safety
Bone and Bones

ASJC Scopus subject areas

  • Hematology
  • Oncology

Cite this

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma : a consensus statement from the International Myeloma Working Group (IMWG). / Kyriakou, Charalampia; Molloy, Sean; Vrionis, Frank; Alberico, Ronald; Bastian, Leonard; Zonder, Jeffrey A.; Giralt, Sergio; Raje, Noopur; Kyle, Robert A.; Roodman, G. David; Dimopoulos, Meletios A.; Rajkumar, S. Vincent; Durie, Brian B.G.; Terpos, Evangelos.

In: Blood Cancer Journal, Vol. 9, No. 3, 27, 01.03.2019.

Research output: Contribution to journalArticle

Kyriakou, Charalampia ; Molloy, Sean ; Vrionis, Frank ; Alberico, Ronald ; Bastian, Leonard ; Zonder, Jeffrey A. ; Giralt, Sergio ; Raje, Noopur ; Kyle, Robert A. ; Roodman, G. David ; Dimopoulos, Meletios A. ; Rajkumar, S. Vincent ; Durie, Brian B.G. ; Terpos, Evangelos. / The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma : a consensus statement from the International Myeloma Working Group (IMWG). In: Blood Cancer Journal. 2019 ; Vol. 9, No. 3.
@article{957f4ff62c98440d82c1ed4ed284d20c,
title = "The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)",
abstract = "Multiple myeloma (MM) represents approximately 15{\%} of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs.",
author = "Charalampia Kyriakou and Sean Molloy and Frank Vrionis and Ronald Alberico and Leonard Bastian and Zonder, {Jeffrey A.} and Sergio Giralt and Noopur Raje and Kyle, {Robert A.} and Roodman, {G. David} and Dimopoulos, {Meletios A.} and Rajkumar, {S. Vincent} and Durie, {Brian B.G.} and Evangelos Terpos",
year = "2019",
month = "3",
day = "1",
doi = "10.1038/s41408-019-0187-7",
language = "English (US)",
volume = "9",
journal = "Blood Cancer Journal",
issn = "2044-5385",
publisher = "Nature Publishing Group",
number = "3",

}

TY - JOUR

T1 - The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma

T2 - a consensus statement from the International Myeloma Working Group (IMWG)

AU - Kyriakou, Charalampia

AU - Molloy, Sean

AU - Vrionis, Frank

AU - Alberico, Ronald

AU - Bastian, Leonard

AU - Zonder, Jeffrey A.

AU - Giralt, Sergio

AU - Raje, Noopur

AU - Kyle, Robert A.

AU - Roodman, G. David

AU - Dimopoulos, Meletios A.

AU - Rajkumar, S. Vincent

AU - Durie, Brian B.G.

AU - Terpos, Evangelos

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs.

AB - Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs.

UR - http://www.scopus.com/inward/record.url?scp=85062065934&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062065934&partnerID=8YFLogxK

U2 - 10.1038/s41408-019-0187-7

DO - 10.1038/s41408-019-0187-7

M3 - Article

C2 - 30808868

AN - SCOPUS:85062065934

VL - 9

JO - Blood Cancer Journal

JF - Blood Cancer Journal

SN - 2044-5385

IS - 3

M1 - 27

ER -