The role of chemotherapy in advanced thymoma

Jordan Schmitt, Patrick J. Loehrer

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Background: Thymoma and thymic carcinomas are rare malignancies. Most thymomas and about one-third of thymic carcinomas can be cured with local therapy. The remainder of will be candidates for systemic therapy. Numerous retrospective trials confirm objective responses to a variety of single-agent and combination chemotherapeutic regimens. Methods: No prospective randomized comparison of regimens has been performed because of the rarity of the disease. This paper reviewed the literature of chemotherapy in advanced thymic malignancies. Results: Existing data suggest that anthracycline plus cisplatin regimens seem to demonstrate higher response rates and perhaps longer median survival times compared with nonanthracycline-containing regimens. Discussion: Thymic malignancies are sensitive to a broad spectrum of systemic agents. Thymic carcinoma has a distinct clinical presentation and worse therapeutic outcomes than thymoma. Despite reproducible high response rates in thymoma, durable complete remissions are rare. Thus, novel new therapeutic targets need to be identified and appropriate agents developed to have further impact on this disease.

Original languageEnglish (US)
Pages (from-to)S357-S360
JournalJournal of Thoracic Oncology
Volume5
Issue number10 SUPPL. 4
DOIs
StatePublished - Oct 2010

Keywords

  • Anthracycline
  • Cisplatin
  • Combination chemotherapy
  • Single agent therapy
  • Thymic carcinoma
  • Thymoma

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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