The Role of cis-Platinum in Solid-Tumor Therapy

Lawrence H. Einhorn, Stephen D. Williams

Research output: Contribution to journalReview article

128 Scopus citations

Abstract

CIS-DIAMMINEDICHLOROPLATINUM (DDP), a heavy metal co-ordination compound with unique antitumor properties, is the first of this type of compound to undergo extensive clinical testing. It has exhibited noteworthy activity in a broad range of solid tumors and represents a major improvement in therapy of some of these neoplasms. Historical Background In 1965 Rosenberg, Van Camp, and Krigas,1 while investigating bacterial growth in an electrical field, noted that current delivered between platinum electrodes inhibited replication of Escherichia coli. Subsequently, it was determined that growth inhibition was not due to the electrical current per se but was caused by certain.

Original languageEnglish (US)
Pages (from-to)289-291
Number of pages3
JournalNew England Journal of Medicine
Volume300
Issue number6
DOIs
StatePublished - Feb 8 1979
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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