The role of constitutively active Stat6 in leukemia and lymphoma

Heather A. Bruns, Mark H. Kaplan

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Signal transducers and activators of transcription (STAT) are a family of transcription factors that regulate a broad range of cellular processes, such as proliferation, differentiation, and survival, in a large variety of cell types. Because of their regulation of diverse cellular functions, their aberrant activation is frequently associated with disease development, particularly oncogenic diseases. Much evidence exists to suggest that STAT proteins play a significant role in cellular transformation. However, which STAT proteins and to what extent they cause transformation and subsequent disease progression are topics currently being investigated. In this review, we will report on the findings concerning the involvement of Stat6 in the development of lymphoma and leukemia. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype.

Original languageEnglish (US)
Pages (from-to)245-253
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume57
Issue number3
DOIs
StatePublished - Mar 1 2006

Fingerprint

STAT Transcription Factors
Lymphoma
Leukemia
Transducers
Disease Progression
Transcription Factors
Phenotype
Survival

Keywords

  • Leukemia
  • Lymphoma
  • Proliferation
  • Stat6

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

The role of constitutively active Stat6 in leukemia and lymphoma. / Bruns, Heather A.; Kaplan, Mark H.

In: Critical Reviews in Oncology/Hematology, Vol. 57, No. 3, 01.03.2006, p. 245-253.

Research output: Contribution to journalReview article

@article{3757b09452f9440d89d1695c53824ced,
title = "The role of constitutively active Stat6 in leukemia and lymphoma",
abstract = "Signal transducers and activators of transcription (STAT) are a family of transcription factors that regulate a broad range of cellular processes, such as proliferation, differentiation, and survival, in a large variety of cell types. Because of their regulation of diverse cellular functions, their aberrant activation is frequently associated with disease development, particularly oncogenic diseases. Much evidence exists to suggest that STAT proteins play a significant role in cellular transformation. However, which STAT proteins and to what extent they cause transformation and subsequent disease progression are topics currently being investigated. In this review, we will report on the findings concerning the involvement of Stat6 in the development of lymphoma and leukemia. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype.",
keywords = "Leukemia, Lymphoma, Proliferation, Stat6",
author = "Bruns, {Heather A.} and Kaplan, {Mark H.}",
year = "2006",
month = "3",
day = "1",
doi = "10.1016/j.critrevonc.2005.08.005",
language = "English (US)",
volume = "57",
pages = "245--253",
journal = "Critical Reviews in Oncology/Hematology",
issn = "1040-8428",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - The role of constitutively active Stat6 in leukemia and lymphoma

AU - Bruns, Heather A.

AU - Kaplan, Mark H.

PY - 2006/3/1

Y1 - 2006/3/1

N2 - Signal transducers and activators of transcription (STAT) are a family of transcription factors that regulate a broad range of cellular processes, such as proliferation, differentiation, and survival, in a large variety of cell types. Because of their regulation of diverse cellular functions, their aberrant activation is frequently associated with disease development, particularly oncogenic diseases. Much evidence exists to suggest that STAT proteins play a significant role in cellular transformation. However, which STAT proteins and to what extent they cause transformation and subsequent disease progression are topics currently being investigated. In this review, we will report on the findings concerning the involvement of Stat6 in the development of lymphoma and leukemia. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype.

AB - Signal transducers and activators of transcription (STAT) are a family of transcription factors that regulate a broad range of cellular processes, such as proliferation, differentiation, and survival, in a large variety of cell types. Because of their regulation of diverse cellular functions, their aberrant activation is frequently associated with disease development, particularly oncogenic diseases. Much evidence exists to suggest that STAT proteins play a significant role in cellular transformation. However, which STAT proteins and to what extent they cause transformation and subsequent disease progression are topics currently being investigated. In this review, we will report on the findings concerning the involvement of Stat6 in the development of lymphoma and leukemia. Mounting evidence, in both patients and mouse models, supports a model where Stat6 is not a mere bystander, but rather, plays an active role in promoting a transformed phenotype.

KW - Leukemia

KW - Lymphoma

KW - Proliferation

KW - Stat6

UR - http://www.scopus.com/inward/record.url?scp=32644434424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32644434424&partnerID=8YFLogxK

U2 - 10.1016/j.critrevonc.2005.08.005

DO - 10.1016/j.critrevonc.2005.08.005

M3 - Review article

C2 - 16213149

AN - SCOPUS:32644434424

VL - 57

SP - 245

EP - 253

JO - Critical Reviews in Oncology/Hematology

JF - Critical Reviews in Oncology/Hematology

SN - 1040-8428

IS - 3

ER -