Purpose of Review: Dipeptidyl peptidase 4 (DPP4, CD26) is a protease that cleaves selected amino acids at the N-terminal penultimate position and has the potential to alter the protein function. The regulation and roles of DPP4 activity are not well understood; therefore, the purpose of this review is to discuss the recent literature regarding DPP4 regulation, as well as the variety of molecules it may affect, and their potential clinical applications. RECENT FINDINGS: Recent insight into the number of proteins that have DPP4 sites, and how DPP4 truncation may alter hematopoiesis based on the protein full length vs. truncated state, has shown that DPP4 truncation of colony-stimulating factors (CSFs) alters their function and that the activity of these CSFs can be enhanced when DPP4 activity is inhibited. DPP4 inhibition has recently been used in a clinical trial to attempt to enhance the engraftment of cord blood cells, and an endogenous DPP4 inhibitor tissue factor pathway inhibitor has been discovered, increasing our understanding of the potential importance of DPP4. SUMMARY: DPP4 plays a role in regulating the activity of CSFs and other cytokines involved in hematopoiesis. This information may be useful for enhancing hematopoietic cell transplantation, blood cell recovery after stress, and for understanding the physiology and pathophysiology of blood and other cell systems.
- Cord blood transplant
- Dipeptidyl peptidase 4
ASJC Scopus subject areas
The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation. / O'Leary, Heather; Ou, Xuan; Broxmeyer, Hal.In: Current Opinion in Hematology, Vol. 20, No. 4, 07.2013, p. 314-319.
Research output: Contribution to journal › Article
TY - JOUR
T1 - The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation
AU - O'Leary, Heather
AU - Ou, Xuan
AU - Broxmeyer, Hal
PY - 2013/7
Y1 - 2013/7
N2 - Lippincott Williams & Wilkins.
AB - Lippincott Williams & Wilkins.
KW - CD26
KW - Cord blood transplant
KW - Dipeptidyl peptidase 4
KW - Hematopoiesis
UR - http://www.scopus.com/inward/record.url?scp=84880197426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880197426&partnerID=8YFLogxK
U2 - 10.1097/MOH.0b013e32836125ac
DO - 10.1097/MOH.0b013e32836125ac
M3 - Article
C2 - 23594692
AN - SCOPUS:84880197426
VL - 20
SP - 314
EP - 319
JO - Current Opinion in Hematology
JF - Current Opinion in Hematology
SN - 1065-6251
IS - 4