The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation

Heather O'Leary, Xuan Ou, Hal Broxmeyer

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Purpose of Review: Dipeptidyl peptidase 4 (DPP4, CD26) is a protease that cleaves selected amino acids at the N-terminal penultimate position and has the potential to alter the protein function. The regulation and roles of DPP4 activity are not well understood; therefore, the purpose of this review is to discuss the recent literature regarding DPP4 regulation, as well as the variety of molecules it may affect, and their potential clinical applications. RECENT FINDINGS: Recent insight into the number of proteins that have DPP4 sites, and how DPP4 truncation may alter hematopoiesis based on the protein full length vs. truncated state, has shown that DPP4 truncation of colony-stimulating factors (CSFs) alters their function and that the activity of these CSFs can be enhanced when DPP4 activity is inhibited. DPP4 inhibition has recently been used in a clinical trial to attempt to enhance the engraftment of cord blood cells, and an endogenous DPP4 inhibitor tissue factor pathway inhibitor has been discovered, increasing our understanding of the potential importance of DPP4. SUMMARY: DPP4 plays a role in regulating the activity of CSFs and other cytokines involved in hematopoiesis. This information may be useful for enhancing hematopoietic cell transplantation, blood cell recovery after stress, and for understanding the physiology and pathophysiology of blood and other cell systems.

Original languageEnglish
Pages (from-to)314-319
Number of pages6
JournalCurrent Opinion in Hematology
Volume20
Issue number4
DOIs
StatePublished - Jul 2013

Fingerprint

Dipeptidyl Peptidase 4
Colony-Stimulating Factors
Hematopoiesis
Blood Cells
Transplantation
Proteins
Cell Transplantation
Fetal Blood
Peptide Hydrolases
Clinical Trials
Cytokines
Amino Acids

Keywords

  • CD26
  • Cord blood transplant
  • Dipeptidyl peptidase 4
  • Hematopoiesis

ASJC Scopus subject areas

  • Hematology

Cite this

The role of dipeptidyl peptidase 4 in hematopoiesis and transplantation. / O'Leary, Heather; Ou, Xuan; Broxmeyer, Hal.

In: Current Opinion in Hematology, Vol. 20, No. 4, 07.2013, p. 314-319.

Research output: Contribution to journalArticle

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