The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies

Djane Braz Duarte, Michael Vasko

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

This chapter discusses the role of DNA damage and repair in Neurotoxicity caused by cancer therapies. These therapies include ionizing radiation, the platinum compounds, alkylating agents such as cyclophosphamide and temozolomide, and the topoisomerase interacting agent doxorubicin. Ionizing radiation produces reactive oxygen species (ROS) which in turn can cause oxidative DNA damage. Platinum compounds interact with DNA to form cross-linking adducts. Recent evidence also suggests that platinum compounds increase production of ROS which can damage DNA and contribute to neurotoxicity. Alkylating agents form covalent bonds with DNA strands, thus preventing cell replication, whereas anticancer antibiotics intercalate into the DNA molecule and this blocks transcription, but also stabilizes the topoisomerase II-DNA complex. Two major clinical issues emerge when considering that various cancer therapies produce these neurotoxicities in a significant number of patients.

Original languageEnglish
Title of host publicationDNA Repair in Cancer Therapy
PublisherElsevier Inc.
Pages283-299
Number of pages17
ISBN (Print)9780123849991
DOIs
StatePublished - 2012

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Platinum Compounds
DNA Repair
DNA Damage
Alkylating Agents
temozolomide
Ionizing Radiation
Reactive Oxygen Species
DNA
Neoplasms
Type II DNA Topoisomerase
Doxorubicin
Cyclophosphamide
Therapeutics
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies. / Duarte, Djane Braz; Vasko, Michael.

DNA Repair in Cancer Therapy. Elsevier Inc., 2012. p. 283-299.

Research output: Chapter in Book/Report/Conference proceedingChapter

Duarte, Djane Braz ; Vasko, Michael. / The Role of DNA Damage and Repair in Neurotoxicity Caused by Cancer Therapies. DNA Repair in Cancer Therapy. Elsevier Inc., 2012. pp. 283-299
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