The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages

Danielle M. Dick, Laura Bierut, Anthony Hinrichs, Louis Fox, Kathleen K. Bucholz, John Kramer, Samuel Kuperman, Victor Hesselbrock, Marc Schuckit, Laura Almasy, Jay Tischfield, Bernice Porjesz, Henri Begleiter, John Nurnberger, Xiaoling Xuei, Howard J. Edenberg, Tatiana Foroud

Research output: Contribution to journalArticlepeer-review

172 Scopus citations

Abstract

We use findings from the behavior genetics literature about how genetic factors (latently) influence alcohol dependence and related disorders to develop and test hypotheses about the risk associated with a specific gene, GABRA2, across different developmental stages. This gene has previously been associated with adult alcohol dependence in the Collaborative Study of the Genetics of Alcoholism (COGA) sample [Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R., Goate, A., Hesselbrock, V., Jones, K. A., Kwon, J., Li, T. K., Nurnberger Jr., J. I., O'Connor, S. J., Reich, T., Rice, J., Schuckit, M., Porjesz, B., Foroud, T., and Begleiter, H. (2004). Am. J. Hum. Genet. 74:705-714] and other studies [Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., and Kranzler, H. R. (2004). Am. J. Med. Genet. B Neuropsychiatr. Genet. 129B:104-109; Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L. K., Covault, J., Kranzler, H. R., Krystal, J., and Gelernter, J. (2005). Alcohol. Clin. Exp. Res. 29:493-498]. In a sample of children and adolescents ascertained as part of the COGA project, we find that GABRA2 is significantly associated with childhood conduct disorder symptoms, but not with childhood alcohol dependence symptoms. A consistent elevation in risk for alcohol dependence associated with GABRA2 is not evident until the mid-20s and then remains throughout adulthood. GABRA2 is also associated with other drug dependence in our sample, both in adolescence and adulthood.

Original languageEnglish (US)
Pages (from-to)577-590
Number of pages14
JournalBehavior Genetics
Volume36
Issue number4
DOIs
StatePublished - Jul 1 2006

Keywords

  • Alcohol
  • Conduct disorder
  • Dependence
  • Drug
  • GABA
  • Substance use

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

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