The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Over the past few years a common theme has emerged in which microbial pathogens grow and cause disease by either expressing their own repertoire of kinases, or by regulating the activity of host-encoded kinases. Toxoplasma gondii is an obligate intracellular parasite that is capable of infecting most nucleated cell types in warm-blooded animals. Within its intermediate hosts, T. gondii exists as two interconvertable stages: dormant bradyzoites, and replicative disease-causing tachyzoites. Tachyzoite growth is achieved by a lytic cycle that is composed of repeated rounds of parasite invasion, replication, and egress. Each of these steps requires the coordinated activity of host and parasite-encoded kinases. In addition to the parasite's lytic cycle, T. gondii-encoded kinases and related pseudokinases that are secreted into the host cell have been identified as key virulence factors. These findings will be highlighted in this chapter, and emerging questions will be discussed.

Original languageEnglish (US)
Title of host publicationProtein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention
Publisherwiley
Pages199-216
Number of pages18
ISBN (Electronic)9783527675401
ISBN (Print)9783527332359
DOIs
StatePublished - Oct 11 2013

Fingerprint

Toxoplasma
Parasites
Phosphotransferases
Virulence Factors
Growth

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Blader, I. J., Arrizabalaga, G., & Sullivan, W. (2013). The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions. In Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention (pp. 199-216). wiley. https://doi.org/10.1002/9783527675401.ch10

The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions. / Blader, Ira J.; Arrizabalaga, Gustavo; Sullivan, William.

Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. wiley, 2013. p. 199-216.

Research output: Chapter in Book/Report/Conference proceedingChapter

Blader, IJ, Arrizabalaga, G & Sullivan, W 2013, The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions. in Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. wiley, pp. 199-216. https://doi.org/10.1002/9783527675401.ch10
Blader IJ, Arrizabalaga G, Sullivan W. The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions. In Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. wiley. 2013. p. 199-216 https://doi.org/10.1002/9783527675401.ch10
Blader, Ira J. ; Arrizabalaga, Gustavo ; Sullivan, William. / The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions. Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention. wiley, 2013. pp. 199-216
@inbook{1c97f30f194544f48408351b2582ab62,
title = "The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions",
abstract = "Over the past few years a common theme has emerged in which microbial pathogens grow and cause disease by either expressing their own repertoire of kinases, or by regulating the activity of host-encoded kinases. Toxoplasma gondii is an obligate intracellular parasite that is capable of infecting most nucleated cell types in warm-blooded animals. Within its intermediate hosts, T. gondii exists as two interconvertable stages: dormant bradyzoites, and replicative disease-causing tachyzoites. Tachyzoite growth is achieved by a lytic cycle that is composed of repeated rounds of parasite invasion, replication, and egress. Each of these steps requires the coordinated activity of host and parasite-encoded kinases. In addition to the parasite's lytic cycle, T. gondii-encoded kinases and related pseudokinases that are secreted into the host cell have been identified as key virulence factors. These findings will be highlighted in this chapter, and emerging questions will be discussed.",
author = "Blader, {Ira J.} and Gustavo Arrizabalaga and William Sullivan",
year = "2013",
month = "10",
day = "11",
doi = "10.1002/9783527675401.ch10",
language = "English (US)",
isbn = "9783527332359",
pages = "199--216",
booktitle = "Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention",
publisher = "wiley",

}

TY - CHAP

T1 - The Role of Host- and Parasite-Encoded Kinases in Toxoplasma-Host Interactions

AU - Blader, Ira J.

AU - Arrizabalaga, Gustavo

AU - Sullivan, William

PY - 2013/10/11

Y1 - 2013/10/11

N2 - Over the past few years a common theme has emerged in which microbial pathogens grow and cause disease by either expressing their own repertoire of kinases, or by regulating the activity of host-encoded kinases. Toxoplasma gondii is an obligate intracellular parasite that is capable of infecting most nucleated cell types in warm-blooded animals. Within its intermediate hosts, T. gondii exists as two interconvertable stages: dormant bradyzoites, and replicative disease-causing tachyzoites. Tachyzoite growth is achieved by a lytic cycle that is composed of repeated rounds of parasite invasion, replication, and egress. Each of these steps requires the coordinated activity of host and parasite-encoded kinases. In addition to the parasite's lytic cycle, T. gondii-encoded kinases and related pseudokinases that are secreted into the host cell have been identified as key virulence factors. These findings will be highlighted in this chapter, and emerging questions will be discussed.

AB - Over the past few years a common theme has emerged in which microbial pathogens grow and cause disease by either expressing their own repertoire of kinases, or by regulating the activity of host-encoded kinases. Toxoplasma gondii is an obligate intracellular parasite that is capable of infecting most nucleated cell types in warm-blooded animals. Within its intermediate hosts, T. gondii exists as two interconvertable stages: dormant bradyzoites, and replicative disease-causing tachyzoites. Tachyzoite growth is achieved by a lytic cycle that is composed of repeated rounds of parasite invasion, replication, and egress. Each of these steps requires the coordinated activity of host and parasite-encoded kinases. In addition to the parasite's lytic cycle, T. gondii-encoded kinases and related pseudokinases that are secreted into the host cell have been identified as key virulence factors. These findings will be highlighted in this chapter, and emerging questions will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=85017338520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017338520&partnerID=8YFLogxK

U2 - 10.1002/9783527675401.ch10

DO - 10.1002/9783527675401.ch10

M3 - Chapter

AN - SCOPUS:85017338520

SN - 9783527332359

SP - 199

EP - 216

BT - Protein Phosphorylation in Parasites: Novel Targets for Antiparasitic Intervention

PB - wiley

ER -