The role of inflammation and inflammatory mediators in the development, progression, metastasis, and chemoresistance of epithelial ovarian cancer

Sudha S. Savant, Shruthi Sriramkumar, Heather M. O’hagan

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Inflammation plays a role in the initiation and development of many types of cancers, including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a type of EOC. There are connections between EOC and both peritoneal and ovulation-induced inflammation. Additionally, EOCs have an inflammatory component that contributes to their progression. At sites of inflammation, epithelial cells are exposed to increased levels of inflammatory mediators such as reactive oxygen species, cytokines, prostaglandins, and growth factors that contribute to increased cell division, and genetic and epigenetic changes. These exposure-induced changes promote excessive cell proliferation, increased survival, malignant transformation, and cancer development. Furthermore, the pro-inflammatory tumor microenvironment environment (TME) contributes to EOC metastasis and chemoresistance. In this review we will discuss the roles inflammation and inflammatory mediators play in the development, progression, metastasis, and chemoresistance of EOC.

Original languageEnglish (US)
Article number251
JournalCancers
Volume10
Issue number8
DOIs
StatePublished - Aug 2018
Externally publishedYes

Keywords

  • Cytokines
  • Epithelial ovarian cancer
  • Growth factors
  • Inflammation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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