The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis

Alan S. Hilibrand, Laurel C. Blakemore, Randall Loder, Mary Lou Greenfield, Frances A. Farley, Robert N. Hensinger, M. Hariharan

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Study Design. A matched, case-control study comparing melatonin production in female patients with and without adolescent idiopathic scoliosis. Objectives. To determine whether melatonin production is decreased in adolescent idiopathic scoliosis. Summary of Background Data. A central etiology for idiopathic scoliosis has never been established. Previous authors have produced experimental scoliosis in chickens after pinealectomy, preventable by administration of melatonin. They suggested that a defect in melatonin synthesis might be involved in the pathogenesis of human idiopathic scoliosis. Methods. Nine female adolescents with no medical problems, normal neurologic examinations, radiographic idiopathic scoliosis of 15-40°, and Risser Stage I-III were in the patient group. Eighteen healthy adolescent girls with no medical problems, a negative school screening, and no family history of scoliosis were control subjects. Patients and control subjects were matched for age, weight, Tanner stage, sleep duration, end light exposure by multiple linear regression. Nighttime and daytime urine samples were analyzed for melatonin by high-performance liquid chromatography. Results. Although nighttime melatonin levels were significantly higher than daytime levels in all volunteers (P <0.00002), there were no significant differences in nighttime (P > 0.63) or daytime (P > 0.78) melatonin levels between patients and control subjects, even after matching by multiple linear regression analysis. A statistical analysis demonstrated that if e melatonin deficiency of 25% or more did exist in patients with scoliosis compared with control subjects, the likelihood that it would have been detected in this study was more than 98%. Conclusion. Although melatonin deficiency may cause scoliosis in the chicken, this study suggests that it is not a mechanism in the pathogenesis of adolescent idiopathic scoliosis in humans.

Original languageEnglish (US)
Pages (from-to)1140-1146
Number of pages7
JournalSpine
Volume21
Issue number10
DOIs
StatePublished - May 15 1996
Externally publishedYes

Fingerprint

Scoliosis
Melatonin
Chickens
Linear Models
Sleep Stages
Neurologic Examination
Case-Control Studies
Volunteers
High Pressure Liquid Chromatography
Regression Analysis
Urine
Light
Weights and Measures

Keywords

  • etiology
  • idiopathic scoliosis
  • melatonin
  • pinealectomy
  • Tanner staging

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Hilibrand, A. S., Blakemore, L. C., Loder, R., Greenfield, M. L., Farley, F. A., Hensinger, R. N., & Hariharan, M. (1996). The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis. Spine, 21(10), 1140-1146. https://doi.org/10.1097/00007632-199605150-00004

The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis. / Hilibrand, Alan S.; Blakemore, Laurel C.; Loder, Randall; Greenfield, Mary Lou; Farley, Frances A.; Hensinger, Robert N.; Hariharan, M.

In: Spine, Vol. 21, No. 10, 15.05.1996, p. 1140-1146.

Research output: Contribution to journalArticle

Hilibrand, AS, Blakemore, LC, Loder, R, Greenfield, ML, Farley, FA, Hensinger, RN & Hariharan, M 1996, 'The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis', Spine, vol. 21, no. 10, pp. 1140-1146. https://doi.org/10.1097/00007632-199605150-00004
Hilibrand AS, Blakemore LC, Loder R, Greenfield ML, Farley FA, Hensinger RN et al. The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis. Spine. 1996 May 15;21(10):1140-1146. https://doi.org/10.1097/00007632-199605150-00004
Hilibrand, Alan S. ; Blakemore, Laurel C. ; Loder, Randall ; Greenfield, Mary Lou ; Farley, Frances A. ; Hensinger, Robert N. ; Hariharan, M. / The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis. In: Spine. 1996 ; Vol. 21, No. 10. pp. 1140-1146.
@article{5c123e55460d4afabc51d0d3dadc2579,
title = "The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis",
abstract = "Study Design. A matched, case-control study comparing melatonin production in female patients with and without adolescent idiopathic scoliosis. Objectives. To determine whether melatonin production is decreased in adolescent idiopathic scoliosis. Summary of Background Data. A central etiology for idiopathic scoliosis has never been established. Previous authors have produced experimental scoliosis in chickens after pinealectomy, preventable by administration of melatonin. They suggested that a defect in melatonin synthesis might be involved in the pathogenesis of human idiopathic scoliosis. Methods. Nine female adolescents with no medical problems, normal neurologic examinations, radiographic idiopathic scoliosis of 15-40°, and Risser Stage I-III were in the patient group. Eighteen healthy adolescent girls with no medical problems, a negative school screening, and no family history of scoliosis were control subjects. Patients and control subjects were matched for age, weight, Tanner stage, sleep duration, end light exposure by multiple linear regression. Nighttime and daytime urine samples were analyzed for melatonin by high-performance liquid chromatography. Results. Although nighttime melatonin levels were significantly higher than daytime levels in all volunteers (P <0.00002), there were no significant differences in nighttime (P > 0.63) or daytime (P > 0.78) melatonin levels between patients and control subjects, even after matching by multiple linear regression analysis. A statistical analysis demonstrated that if e melatonin deficiency of 25{\%} or more did exist in patients with scoliosis compared with control subjects, the likelihood that it would have been detected in this study was more than 98{\%}. Conclusion. Although melatonin deficiency may cause scoliosis in the chicken, this study suggests that it is not a mechanism in the pathogenesis of adolescent idiopathic scoliosis in humans.",
keywords = "etiology, idiopathic scoliosis, melatonin, pinealectomy, Tanner staging",
author = "Hilibrand, {Alan S.} and Blakemore, {Laurel C.} and Randall Loder and Greenfield, {Mary Lou} and Farley, {Frances A.} and Hensinger, {Robert N.} and M. Hariharan",
year = "1996",
month = "5",
day = "15",
doi = "10.1097/00007632-199605150-00004",
language = "English (US)",
volume = "21",
pages = "1140--1146",
journal = "Spine",
issn = "0362-2436",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - The role of melatonin in the pathogenesis of adolescent idiopathic scoliosis

AU - Hilibrand, Alan S.

AU - Blakemore, Laurel C.

AU - Loder, Randall

AU - Greenfield, Mary Lou

AU - Farley, Frances A.

AU - Hensinger, Robert N.

AU - Hariharan, M.

PY - 1996/5/15

Y1 - 1996/5/15

N2 - Study Design. A matched, case-control study comparing melatonin production in female patients with and without adolescent idiopathic scoliosis. Objectives. To determine whether melatonin production is decreased in adolescent idiopathic scoliosis. Summary of Background Data. A central etiology for idiopathic scoliosis has never been established. Previous authors have produced experimental scoliosis in chickens after pinealectomy, preventable by administration of melatonin. They suggested that a defect in melatonin synthesis might be involved in the pathogenesis of human idiopathic scoliosis. Methods. Nine female adolescents with no medical problems, normal neurologic examinations, radiographic idiopathic scoliosis of 15-40°, and Risser Stage I-III were in the patient group. Eighteen healthy adolescent girls with no medical problems, a negative school screening, and no family history of scoliosis were control subjects. Patients and control subjects were matched for age, weight, Tanner stage, sleep duration, end light exposure by multiple linear regression. Nighttime and daytime urine samples were analyzed for melatonin by high-performance liquid chromatography. Results. Although nighttime melatonin levels were significantly higher than daytime levels in all volunteers (P <0.00002), there were no significant differences in nighttime (P > 0.63) or daytime (P > 0.78) melatonin levels between patients and control subjects, even after matching by multiple linear regression analysis. A statistical analysis demonstrated that if e melatonin deficiency of 25% or more did exist in patients with scoliosis compared with control subjects, the likelihood that it would have been detected in this study was more than 98%. Conclusion. Although melatonin deficiency may cause scoliosis in the chicken, this study suggests that it is not a mechanism in the pathogenesis of adolescent idiopathic scoliosis in humans.

AB - Study Design. A matched, case-control study comparing melatonin production in female patients with and without adolescent idiopathic scoliosis. Objectives. To determine whether melatonin production is decreased in adolescent idiopathic scoliosis. Summary of Background Data. A central etiology for idiopathic scoliosis has never been established. Previous authors have produced experimental scoliosis in chickens after pinealectomy, preventable by administration of melatonin. They suggested that a defect in melatonin synthesis might be involved in the pathogenesis of human idiopathic scoliosis. Methods. Nine female adolescents with no medical problems, normal neurologic examinations, radiographic idiopathic scoliosis of 15-40°, and Risser Stage I-III were in the patient group. Eighteen healthy adolescent girls with no medical problems, a negative school screening, and no family history of scoliosis were control subjects. Patients and control subjects were matched for age, weight, Tanner stage, sleep duration, end light exposure by multiple linear regression. Nighttime and daytime urine samples were analyzed for melatonin by high-performance liquid chromatography. Results. Although nighttime melatonin levels were significantly higher than daytime levels in all volunteers (P <0.00002), there were no significant differences in nighttime (P > 0.63) or daytime (P > 0.78) melatonin levels between patients and control subjects, even after matching by multiple linear regression analysis. A statistical analysis demonstrated that if e melatonin deficiency of 25% or more did exist in patients with scoliosis compared with control subjects, the likelihood that it would have been detected in this study was more than 98%. Conclusion. Although melatonin deficiency may cause scoliosis in the chicken, this study suggests that it is not a mechanism in the pathogenesis of adolescent idiopathic scoliosis in humans.

KW - etiology

KW - idiopathic scoliosis

KW - melatonin

KW - pinealectomy

KW - Tanner staging

UR - http://www.scopus.com/inward/record.url?scp=0029982363&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029982363&partnerID=8YFLogxK

U2 - 10.1097/00007632-199605150-00004

DO - 10.1097/00007632-199605150-00004

M3 - Article

C2 - 8727187

AN - SCOPUS:0029982363

VL - 21

SP - 1140

EP - 1146

JO - Spine

JF - Spine

SN - 0362-2436

IS - 10

ER -