The role of menin in hematopoiesis

Jay L. Hess, Ivan Maillard

Research output: Chapter in Book/Report/Conference proceedingChapter

7 Scopus citations


In the hematopoietic system, menin wasfound to interact with MLL, a largeprotein encoded by the mixedlinageleukemiagenethat actsasa histone H3 merhyltransferase.The MLL gene is a recurrent target for translocations in both acute myeloidand acute lymphoid leukemias. MLL gene rearrangementsinvolvea varietyoftranslocation partners, givingrise to MLL fusion proteins whose transforming ability is mediated through upregulated expression of Homeobox (Hox) genes as well as other targets. Recent work indicates that menin is an essentialparmer of MLL fusion proteins in leukemiccellsand that it regulatesnormal hematopoiesis. In the absence of menin, steady-state hematopoiesisislargely preserved; however, menin-deficienr hematopoietic stem cellsaremarkedlydeficientin situationsofhematopoietic stress, such asduring recoveryafter bone marrow transplantation. In leukemias driven by MLL fusion proteins, menin is essential for transformation and growth ofthe malignant cells. Thus, menin-Ml.L interactions represent a promising therapeutic target in leukemiaswith MLL rearrangements.

Original languageEnglish (US)
Title of host publicationSuperMEN1
Subtitle of host publicationPituitary, Parathyroid and Pancreas
EditorsKatalin Balogh, Atilla Patocs
Number of pages7
StatePublished - 2009

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Hess, J. L., & Maillard, I. (2009). The role of menin in hematopoiesis. In K. Balogh, & A. Patocs (Eds.), SuperMEN1: Pituitary, Parathyroid and Pancreas (pp. 51-57). (Advances in Experimental Medicine and Biology; Vol. 668).