The role of menin in hematopoiesis

Jay Hess, Ivan Maillard

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Citations (Scopus)

Abstract

In the hematopoietic system, menin wasfound to interact with MLL, a largeprotein encoded by the mixedlinageleukemiagenethat actsasa histone H3 merhyltransferase.The MLL gene is a recurrent target for translocations in both acute myeloidand acute lymphoid leukemias. MLL gene rearrangementsinvolvea varietyoftranslocation partners, givingrise to MLL fusion proteins whose transforming ability is mediated through upregulated expression of Homeobox (Hox) genes as well as other targets. Recent work indicates that menin is an essentialparmer of MLL fusion proteins in leukemiccellsand that it regulatesnormal hematopoiesis. In the absence of menin, steady-state hematopoiesisislargely preserved; however, menin-deficienr hematopoietic stem cellsaremarkedlydeficientin situationsofhematopoietic stress, such asduring recoveryafter bone marrow transplantation. In leukemias driven by MLL fusion proteins, menin is essential for transformation and growth ofthe malignant cells. Thus, menin-Ml.L interactions represent a promising therapeutic target in leukemiaswith MLL rearrangements.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages51-57
Number of pages7
Volume668
StatePublished - 2009
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume668
ISSN (Print)00652598

Fingerprint

Hematopoiesis
Fusion reactions
Genes
Hematopoietic System
Proteins
Homeobox Genes
Bone Marrow Transplantation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Histones
Bone
Leukemia
Growth
Therapeutics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Hess, J., & Maillard, I. (2009). The role of menin in hematopoiesis. In Advances in Experimental Medicine and Biology (Vol. 668, pp. 51-57). (Advances in Experimental Medicine and Biology; Vol. 668).

The role of menin in hematopoiesis. / Hess, Jay; Maillard, Ivan.

Advances in Experimental Medicine and Biology. Vol. 668 2009. p. 51-57 (Advances in Experimental Medicine and Biology; Vol. 668).

Research output: Chapter in Book/Report/Conference proceedingChapter

Hess, J & Maillard, I 2009, The role of menin in hematopoiesis. in Advances in Experimental Medicine and Biology. vol. 668, Advances in Experimental Medicine and Biology, vol. 668, pp. 51-57.
Hess J, Maillard I. The role of menin in hematopoiesis. In Advances in Experimental Medicine and Biology. Vol. 668. 2009. p. 51-57. (Advances in Experimental Medicine and Biology).
Hess, Jay ; Maillard, Ivan. / The role of menin in hematopoiesis. Advances in Experimental Medicine and Biology. Vol. 668 2009. pp. 51-57 (Advances in Experimental Medicine and Biology).
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