The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease

Dilara Seyidova, Ali Aliyev, Nizami Rzayev, Mark Obrenovich, Bruce Lamb, Mark A. Smith, Jack C. De La Torre, George Perry, Gjumrakch Aliev

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Nitric oxide (NO) is a key bioregulatory active molecule in the cardiovascular, immune and nervous systems, synthesized through converting L-arginine to L-citrulline by NO synthase (NOS). Research exploration supports the theory that this molecule appears to be one of the key factors for the disruption of normal brain homeostasis, which causes the development of brain lesions and pathology such as in Allzheimer's disease (AD). Especially the vascular content of NO activity appears to be a major contributor to this pathology before the overexpression of NOS activity in other brain cellular compartments develop. We theorize that pharmacological intervention using NO donors and/or NO suppressors should delay or minimize brain lesion development and further progression of brain pathology and dementia.

Original languageEnglish (US)
Pages (from-to)325-334
Number of pages10
JournalIn Vivo
Volume18
Issue number3
StatePublished - May 2004
Externally publishedYes

Fingerprint

Brain
Alzheimer Disease
Nitric Oxide
Pathology
Nitric Oxide Synthase
Cardiovascular system
Citrulline
Molecules
Nitric Oxide Donors
Immune system
Neurology
Cardiovascular System
Nervous System
Blood Vessels
Arginine
Dementia
Immune System
Homeostasis
Pharmacology
Research

Keywords

  • Alzheimer's disease
  • Hypoperfusion
  • Nitric oxide
  • Review
  • Vessel lesion

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Seyidova, D., Aliyev, A., Rzayev, N., Obrenovich, M., Lamb, B., Smith, M. A., ... Aliev, G. (2004). The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In Vivo, 18(3), 325-334.

The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. / Seyidova, Dilara; Aliyev, Ali; Rzayev, Nizami; Obrenovich, Mark; Lamb, Bruce; Smith, Mark A.; De La Torre, Jack C.; Perry, George; Aliev, Gjumrakch.

In: In Vivo, Vol. 18, No. 3, 05.2004, p. 325-334.

Research output: Contribution to journalArticle

Seyidova, D, Aliyev, A, Rzayev, N, Obrenovich, M, Lamb, B, Smith, MA, De La Torre, JC, Perry, G & Aliev, G 2004, 'The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease', In Vivo, vol. 18, no. 3, pp. 325-334.
Seyidova D, Aliyev A, Rzayev N, Obrenovich M, Lamb B, Smith MA et al. The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In Vivo. 2004 May;18(3):325-334.
Seyidova, Dilara ; Aliyev, Ali ; Rzayev, Nizami ; Obrenovich, Mark ; Lamb, Bruce ; Smith, Mark A. ; De La Torre, Jack C. ; Perry, George ; Aliev, Gjumrakch. / The role of nitric oxide in the pathogenesis of brain lesions during the development of Alzheimer's disease. In: In Vivo. 2004 ; Vol. 18, No. 3. pp. 325-334.
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