The role of nonsteroidal anti-inflammatory medications and exercise in the treatment of ankylosing spondylitis

Mazen Elyan, Muhammad Asim Khan

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Ankylosing spondylitis (AS) is a chronic systemic rheumatic disease that primarily affects the sacroiliac joints and spine. Even with the development of tumor necrosis factor-α inhibitors, which have revolutionized the treatment of this disease, the combination of nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy, and a life-long exercise program still form the first step in its management. Multiple clinical trials have addressed the efficacy and safety of both nonselective and selective NSAIDs. Gastrointestinal toxicity remains their major side effect, with increased concern about the potential of cardiovascular toxicity, especially with the selective cyclooxygenase-2 inhibitors. A specific set of recommendations has been proposed for the management of AS.

Original languageEnglish (US)
Pages (from-to)255-259
Number of pages5
JournalCurrent rheumatology reports
Volume8
Issue number4
DOIs
StatePublished - Aug 1 2006

ASJC Scopus subject areas

  • Rheumatology

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