The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease

Gjumrakch Aliev, Mark A. Smith, Dilara Seyidova, Maxwell Lewis Neal, Bruce T. Lamb, Akihiko Nunomura, Eldar K. Gasimov, Harry V. Vinters, George Perry, Joseph C. Lamanna, Robert P. Friedland

Research output: Contribution to journalReview article

148 Scopus citations

Abstract

Alzheimer's disease (AD) and stroke are two leading causes of age-associated dementia. A rapidly growing body of evidence indicates that increased oxidative stress from reactive oxygen radicals is associated with the aging process and age-related degenerative disorders such as atherosclerosis, ischemia/reperfusion, arthritis, stroke, and neurodegenerative diseases. New evidence has also indicated that vascular lesions are a key factor in the development of AD. This idea is based on a positive correlation between AD and cardiovascular and cerebrovascular diseases such as arterio- and atherosclerosis and ischemia/reperfusion injury. In this review we consider recent evidence supporting the existence of an intimate relationship between oxidative stress and vascular lesions in the pathobiology of AD. We also consider the opportunities for therapeutic interventions based on the molecular pathways involved with these causal relationships.

Original languageEnglish (US)
Pages (from-to)21-35
Number of pages15
JournalBrain Pathology
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2002

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

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    Aliev, G., Smith, M. A., Seyidova, D., Neal, M. L., Lamb, B. T., Nunomura, A., Gasimov, E. K., Vinters, H. V., Perry, G., Lamanna, J. C., & Friedland, R. P. (2002). The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease. Brain Pathology, 12(1), 21-35. https://doi.org/10.1111/j.1750-3639.2002.tb00419.x