The role of pancreaticoduodenectomy for locally recurrent or metastatic carcinoma to the periampullary region

Attila Nakeeb, K. D. Lillemoe, J. L. Cameron

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

BACKGROUND: The efficacy of operative resection of metastatic lesions to the liver, lung, and brain is well established. However, the appropriate management of metastatic or locally recurrent malignancies to the periampullary region is less well established. STUDY DESIGN: A retrospective review of The Johns Hopkins Hospital experience with pancreaticoduodenectomy for metastatic or locally recurrent periampullary lesions was performed. RESULTS: From 1988 to 1993, 27 patients with a past history of malignancy underwent pancreaticoduodenectomy. In six patients (22 percent), the lesion was determined to be from a metastasis or a local recurrence, and in 21 patients (78 percent), the lesion was a new primary. Patients with metastatic or locally recurrent lesions were younger (51.3 compared to 67.1 years of age) and presented with a shorter interval from their initial neoplasm (33 compared to 120 months). Of the six patients undergoing pancreaticoduodenectomy for a metastatic or locally recurrent lesion, three patients are alive an average of 38 months and three patients died an average of 11 months postoperatively. This compares favorably with the survival rate of the new primary group in which 12 patients are alive a mean of 22 months and nine patients died a mean of 14 months postoperatively. CONCLUSIONS: These results suggest that patients with metastatic or locally recurrent lesions in the periampullary region from a previously treated neoplasm should be considered candidates for pancreaticoduodenectomy.

Original languageEnglish (US)
Pages (from-to)188-192
Number of pages5
JournalJournal of the American College of Surgeons
Volume180
Issue number2
StatePublished - 1995
Externally publishedYes

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Pancreaticoduodenectomy
Carcinoma
Neoplasms
Survival Rate
Neoplasm Metastasis
Recurrence
Lung

ASJC Scopus subject areas

  • Surgery

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The role of pancreaticoduodenectomy for locally recurrent or metastatic carcinoma to the periampullary region. / Nakeeb, Attila; Lillemoe, K. D.; Cameron, J. L.

In: Journal of the American College of Surgeons, Vol. 180, No. 2, 1995, p. 188-192.

Research output: Contribution to journalArticle

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