The role of periostin in tissue remodeling across health and disease

Simon J. Conway, Kenji Izuhara, Yasusei Kudo, Judith Litvin, Roger Markwald, Gaoliang Ouyang, Joseph R. Arron, Cecile T.J. Holweg, Akira Kudo

Research output: Contribution to journalReview article

184 Scopus citations


Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial-mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.

Original languageEnglish (US)
Pages (from-to)1279-1288
Number of pages10
JournalCellular and Molecular Life Sciences
Issue number7
StatePublished - Apr 1 2014


  • Extracellular matrix
  • Periostin
  • Remodeling
  • Repair

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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  • Cite this

    Conway, S. J., Izuhara, K., Kudo, Y., Litvin, J., Markwald, R., Ouyang, G., Arron, J. R., Holweg, C. T. J., & Kudo, A. (2014). The role of periostin in tissue remodeling across health and disease. Cellular and Molecular Life Sciences, 71(7), 1279-1288.