The role of pharmacology in ureteral physiology and expulsive therapy

Travis J. Jerde, Stephen Y. Nakada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Research in the field of ureteral physiology and pharmacology has traditionally been directed toward relaxation of ureteral spasm as a mechanism of analgesia during painful ureteral obstruction, most often stone-induced episodes. However, interest in this field has expanded greatly in recent years with the expanded use of alpha-blocker therapy for inducing stone passage, a usage now termed "medical expulsive therapy". While most clinical reports involving expulsive therapy have focused on alpha receptor or calcium channel blockade, there are diverse studies investigating pharmacological ureteral relaxation with novel agents including cyclooxygenase inhibitors, small molecule beta receptor agonists, neurokinin antagonists, and phosphodiesterase inhibitors. In addition, cutting edge molecular biology research is revealing promising potential therapeutic targets aimed at specific molecular changes that occur during the acute obstruction that accompanies stone disease. The purpose of this report is to review the use of pharmacological agents as ureteral smooth muscle relaxants clinically, and to look into the future of expulsive therapy by reviewing the available literature of ureteral physiology and pharmacology research.

Original languageEnglish (US)
Title of host publicationRENAL STONE DISEASE
Subtitle of host publication1st Annual International Urolithiasis Research Symposium
PublisherAmerican Institute of Physics Inc.
Pages262-271
Number of pages10
ISBN (Print)0735404062, 9780735404069
DOIs
StatePublished - Jan 1 2007
Event1st Annual International Urolithiasis Research Symposium - Indianapolis, IN, United States
Duration: Nov 2 2006Nov 3 2006

Publication series

NameAIP Conference Proceedings
Volume900
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other1st Annual International Urolithiasis Research Symposium
CountryUnited States
CityIndianapolis, IN
Period11/2/0611/3/06

Keywords

  • Expulsive therapy
  • Pharmacology
  • Relaxation
  • Smooth muscle
  • Ureter

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Jerde, T. J., & Nakada, S. Y. (2007). The role of pharmacology in ureteral physiology and expulsive therapy. In RENAL STONE DISEASE: 1st Annual International Urolithiasis Research Symposium (pp. 262-271). (AIP Conference Proceedings; Vol. 900). American Institute of Physics Inc.. https://doi.org/10.1063/1.2723585