The role of phospholipase A2 in lipid peroxidation-induced fall of membrane potential of rat liver mitochondria

V. G. Gogvadze, N. N. Brustovetsky, A. A. Zhukova

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Cumene hydroperoxide (230 μM)-induced fall of the membrane potential takes place only in Ca2+ -loaded mitochondria. Inhibitor of phospholipase A2, P-bromphenacyl bromide prevents uncoupling of mitochondria, having no effect on the accumulation of lipid peroxidation products.

Original languageEnglish (US)
Pages (from-to)168-170
Number of pages3
JournalFEBS Letters
Volume264
Issue number2
DOIs
StatePublished - May 21 1990
Externally publishedYes

Keywords

  • Calcium
  • Lipid peroxidation
  • Mitochondria
  • Phospholipase A

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Fingerprint Dive into the research topics of 'The role of phospholipase A<sub>2</sub> in lipid peroxidation-induced fall of membrane potential of rat liver mitochondria'. Together they form a unique fingerprint.

  • Cite this