The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period

Leslie Abrams Tobe, Alon Harris, Rehan M. Hussain, George Eckert, Andrew Huck, Joshua Park, Patrick Egan, Nathaniel J. Kim, Brent Siesky

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Background/aims: Evidence suggests that vascular abnormalities play a role in the pathogenesis of openangle glaucoma (OAG) in some patients. This study aims to assess changes in retrobulbar and retinal blood flow over time in patients with glaucoma and examine their relationship to glaucomatous progression, as determined by retinal and optic nerve structure. Methods: In this observational study, 103 patients with OAG were examined at baseline and 18 months followup. Retrobulbar blood flow was measured by colour Doppler imaging in the ophthalmic, central retinal and temporal posterior ciliary artery (TPCA) and nasal short posterior ciliary artery. Retinal capillary blood flow was measured by confocal scanning laser Doppler. Peripapillary retinal nerve fibre layer thickness was assessed by optical coherence tomography. Nonparametric Wilcoxon signed ranks tests were used to assess for any statistically significant changes between the baseline and 18-month visits for the retrobulbar and retinal flow, as well as the structural parameters. Results: In general, retinal and retrobulbar blood flow parameters decreased over 18 months. Thinning of the optic disc rim and increase in cup area were associated with a higher resistance index (p=0.0334) and lower peak systolic velocity of TPCA (p=0.0282), respectively. A higher amount of retinal zero pixel blood flow correlated with a greater increase in cup/disc ratio (p=0.0170). Conclusions: Reductions in retrobulbar and retinal blood flow over time were associated with structural glaucomatous progression, as indicated by retinal and optic nerve changes.

Original languageEnglish
Pages (from-to)609-612
Number of pages4
JournalBritish Journal of Ophthalmology
Volume99
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

Open Angle Glaucoma
Optic Disk
Nerve Fibers
Ciliary Arteries
Glaucoma
Optic Nerve
Optical Coherence Tomography
Nonparametric Statistics
Nose
Observational Studies
Blood Vessels
Lasers
Color

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period. / Tobe, Leslie Abrams; Harris, Alon; Hussain, Rehan M.; Eckert, George; Huck, Andrew; Park, Joshua; Egan, Patrick; Kim, Nathaniel J.; Siesky, Brent.

In: British Journal of Ophthalmology, Vol. 99, No. 5, 01.05.2015, p. 609-612.

Research output: Contribution to journalArticle

Tobe, Leslie Abrams ; Harris, Alon ; Hussain, Rehan M. ; Eckert, George ; Huck, Andrew ; Park, Joshua ; Egan, Patrick ; Kim, Nathaniel J. ; Siesky, Brent. / The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period. In: British Journal of Ophthalmology. 2015 ; Vol. 99, No. 5. pp. 609-612.
@article{e770ee369b5d4b5c87575c314fe4653d,
title = "The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period",
abstract = "Background/aims: Evidence suggests that vascular abnormalities play a role in the pathogenesis of openangle glaucoma (OAG) in some patients. This study aims to assess changes in retrobulbar and retinal blood flow over time in patients with glaucoma and examine their relationship to glaucomatous progression, as determined by retinal and optic nerve structure. Methods: In this observational study, 103 patients with OAG were examined at baseline and 18 months followup. Retrobulbar blood flow was measured by colour Doppler imaging in the ophthalmic, central retinal and temporal posterior ciliary artery (TPCA) and nasal short posterior ciliary artery. Retinal capillary blood flow was measured by confocal scanning laser Doppler. Peripapillary retinal nerve fibre layer thickness was assessed by optical coherence tomography. Nonparametric Wilcoxon signed ranks tests were used to assess for any statistically significant changes between the baseline and 18-month visits for the retrobulbar and retinal flow, as well as the structural parameters. Results: In general, retinal and retrobulbar blood flow parameters decreased over 18 months. Thinning of the optic disc rim and increase in cup area were associated with a higher resistance index (p=0.0334) and lower peak systolic velocity of TPCA (p=0.0282), respectively. A higher amount of retinal zero pixel blood flow correlated with a greater increase in cup/disc ratio (p=0.0170). Conclusions: Reductions in retrobulbar and retinal blood flow over time were associated with structural glaucomatous progression, as indicated by retinal and optic nerve changes.",
author = "Tobe, {Leslie Abrams} and Alon Harris and Hussain, {Rehan M.} and George Eckert and Andrew Huck and Joshua Park and Patrick Egan and Kim, {Nathaniel J.} and Brent Siesky",
year = "2015",
month = "5",
day = "1",
doi = "10.1136/bjophthalmol-2014-305780",
language = "English",
volume = "99",
pages = "609--612",
journal = "British Journal of Ophthalmology",
issn = "0007-1161",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - The role of retrobulbar and retinal circulation on optic nerve head and retinal nerve fibre layer structure in patients with open-angle glaucoma over an 18-month period

AU - Tobe, Leslie Abrams

AU - Harris, Alon

AU - Hussain, Rehan M.

AU - Eckert, George

AU - Huck, Andrew

AU - Park, Joshua

AU - Egan, Patrick

AU - Kim, Nathaniel J.

AU - Siesky, Brent

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Background/aims: Evidence suggests that vascular abnormalities play a role in the pathogenesis of openangle glaucoma (OAG) in some patients. This study aims to assess changes in retrobulbar and retinal blood flow over time in patients with glaucoma and examine their relationship to glaucomatous progression, as determined by retinal and optic nerve structure. Methods: In this observational study, 103 patients with OAG were examined at baseline and 18 months followup. Retrobulbar blood flow was measured by colour Doppler imaging in the ophthalmic, central retinal and temporal posterior ciliary artery (TPCA) and nasal short posterior ciliary artery. Retinal capillary blood flow was measured by confocal scanning laser Doppler. Peripapillary retinal nerve fibre layer thickness was assessed by optical coherence tomography. Nonparametric Wilcoxon signed ranks tests were used to assess for any statistically significant changes between the baseline and 18-month visits for the retrobulbar and retinal flow, as well as the structural parameters. Results: In general, retinal and retrobulbar blood flow parameters decreased over 18 months. Thinning of the optic disc rim and increase in cup area were associated with a higher resistance index (p=0.0334) and lower peak systolic velocity of TPCA (p=0.0282), respectively. A higher amount of retinal zero pixel blood flow correlated with a greater increase in cup/disc ratio (p=0.0170). Conclusions: Reductions in retrobulbar and retinal blood flow over time were associated with structural glaucomatous progression, as indicated by retinal and optic nerve changes.

AB - Background/aims: Evidence suggests that vascular abnormalities play a role in the pathogenesis of openangle glaucoma (OAG) in some patients. This study aims to assess changes in retrobulbar and retinal blood flow over time in patients with glaucoma and examine their relationship to glaucomatous progression, as determined by retinal and optic nerve structure. Methods: In this observational study, 103 patients with OAG were examined at baseline and 18 months followup. Retrobulbar blood flow was measured by colour Doppler imaging in the ophthalmic, central retinal and temporal posterior ciliary artery (TPCA) and nasal short posterior ciliary artery. Retinal capillary blood flow was measured by confocal scanning laser Doppler. Peripapillary retinal nerve fibre layer thickness was assessed by optical coherence tomography. Nonparametric Wilcoxon signed ranks tests were used to assess for any statistically significant changes between the baseline and 18-month visits for the retrobulbar and retinal flow, as well as the structural parameters. Results: In general, retinal and retrobulbar blood flow parameters decreased over 18 months. Thinning of the optic disc rim and increase in cup area were associated with a higher resistance index (p=0.0334) and lower peak systolic velocity of TPCA (p=0.0282), respectively. A higher amount of retinal zero pixel blood flow correlated with a greater increase in cup/disc ratio (p=0.0170). Conclusions: Reductions in retrobulbar and retinal blood flow over time were associated with structural glaucomatous progression, as indicated by retinal and optic nerve changes.

UR - http://www.scopus.com/inward/record.url?scp=84928178111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928178111&partnerID=8YFLogxK

U2 - 10.1136/bjophthalmol-2014-305780

DO - 10.1136/bjophthalmol-2014-305780

M3 - Article

C2 - 25467967

AN - SCOPUS:84928178111

VL - 99

SP - 609

EP - 612

JO - British Journal of Ophthalmology

JF - British Journal of Ophthalmology

SN - 0007-1161

IS - 5

ER -