The role of statins in endothelial dysfunction in hypertension

Kunal Sarkar, Anjan K. Sinha, Jawahar L. Mehta

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

PURPOSE OF REVIEW: Hypertension and dyslipidemia frequently coexist, and endothelial dysfunction is associated with the pathophysiology of both atherosclerosis and hypertension. Evidence is convincing for an overlapping role of oxidative stress, renin-angiotensin system activation, and dyslipidemia in the genesis of endothelial dysfunction. RECENT FINDINGS: Ample experimental and human data suggest that common cellular pathways are involved in the pathogenesis of hypertension, increased vascular resistance, and plaque formation. Multiple interventions such as dietary modification, exercise, antioxidants, and antihypertensive drugs improve endothelial dysfunction in hypertension. Statin drugs are a cornerstone of dyslipidemia therapy. Studies have demonstrated that statins correct endothelial function and vascular stiffening and may be useful in reducing blood pressure to target levels. SUMMARY: Statins may be a useful adjunct in the treatment of hypertension in patients with dyslipidemia and possibly those with normal cholesterol levels.

Original languageEnglish (US)
Pages (from-to)316-321
Number of pages6
JournalCurrent Opinion in Cardiology
Volume21
Issue number4
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

Keywords

  • Dyslipidemia
  • Endothelial dysfunction
  • Hypertension
  • Oxidative stress
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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